摘要
目的观察快速肠道准备对结直肠术后肠道黏膜屏障功能的影响。方法 2008年1月-2010年12月行结直肠手术患者70例随机分为观察组和对照组,每组35例。观察组患者口服复方聚乙二醇电解质散、对照组患者口服硫酸镁溶液进行快速肠道准备。分别于肠道准备前,手术后第2、4、8天测定2组患者尿乳果糖与甘露醇的比值、血浆谷氨酰胺、外周血细菌DNA。结果 2组患者术后尿乳果糖与甘露醇的比值和血浆谷氨酰胺以术后第2天最高,第4天和第8天逐渐降低;组问比较差异有统计学意义(P<0.01);2组患者术前外周血细菌DNA均呈阴性,术后2组中部分患者外周血细菌DNA部分呈阳性,但血细菌DNA阳性率比较差异无统计学意义(P>0.05)。结论应用复方聚乙二醇电解质散快速肠道准备可改善结直肠手术患者肠黏膜屏障功能,可能与改善结直肠患者肠道黏膜通透性、升高谷氨酰胺以及抑制肠道细菌移位有关。
Objective To investigate the effects of rapid bowel preparation on intestinal mucosa barrier in patients with colorectal surgery. Methods A total of 70 patients underwent intestinal surgery in general surgery department from January 2008 to December 2010 were randomly divided into observation group and control group （35 cases in each group）. Both groups received rapid bowel preparation by oral administration of compound polyethylene glycol scattered electrolyte in observation group and magnesium sulfate in control group, respectiVely. Ratio of lactulose and mannitol in urine, gluLamine level in plasma and bacterial DNA in peripheral blood were determined before operation, 2nd, 4th and 8th day after operation. Results Ratio of lactulLose and mannitol in urine and glutamine level in plasma on 2nd day after operation was the highest, then were gradually decreased on 4th and 8th d.~y after operation, and there was significant difference between groups （ P 〈 0.01 ）. Bacterial DNA in peripheral blood in both groups were negative, and there were some patients with positive DNA in peripheral blood, but there was no significant difference between the two groups （P 〉 0.05 ）. Conclusion Compared with magnesium sulfate,compound polyethylene glycol scattered electrolyte can protect the intestinal mucosa barrier by improving the permeability of intestinal mucosa and increasing glutamine level in plasma, and preventing the endotoxin translocation from intestine caused by trauma.
出处
《河北医科大学学报》
CAS
2012年第2期157-160,共4页
Journal of Hebei Medical University
关键词
结直肠外科手术
肠黏膜
聚乙烯二醇类
colorectal surgery
intestinal mucosa
polyethylene glycols
