摘要
目的观察PEG-IFN α-2a小剂量长疗程治疗慢性丙型肝炎患者的病毒学应答。方法选择2004年9月至2006年9月住院的慢性丙型肝炎患者92例，根据对干扰素耐受情况将其分为A组（PEG—IFN α-2a 67．5μg／周）、B组（PEG—IFN α-2a 90μg／周）及C组（PEG-IFN α-2a 180μg／周），同时联合利巴韦林（900～1200mg／d）。A组和B组中HCV基因1b型患者疗程延长至96周，2a型疗程48周；C组HCV基因1b型疗程48周，2a型疗程24周，均随访24周；分别观察各组患者的快速病毒学应答（RVR）、早期病毒学应答（EVR）及持续病毒学应答（SVR）率。结果三组RVR、EVR、SVR率之间无统计学差异（P〉0．05），基因1b型患者的RVR、EVR和SVR率明显低于2a型（P〈0．05），经logistic回归分析，HCV基因型为SVR独立预测因子（OR=12．78，95％CI=11．97—82．89，P=0．0075）。结论小剂量长疗程PEG—IFN α-2a联合利巴韦林与标准方案治疗慢性丙型肝炎病毒学应答状况相当；基因型是SVR的独立预测因素。
Objective To investigate the virological response in prolonged therapy of chronic hepatitis C （CHC） with low-dose peginterferon alpha-2a. Methods The 92 cases of in-patients with chronic hepatitis C in September 2004 to September 2006 were divided to three groups according the endurance of interferon. The dose of peginterferon alpha-2a was 67.5 μg, 90 μg and 180 μg per week in group A,B and C respectively. The treatment duration of peginterferon alpha-2a was 96 or 48 weeks in HCV genotype lb and 2a in group A and B, and in the group C the duration was 48 or 24 weeks in genotype lb and 2a patients respectively. Meanwhile, ribavirin for 900--1200 mg per day combined treated with all patients. The quantitation of serum HCV RNA were conducted to determine the rapid virological response （RVR） , early virological response （EVR） and sustained virological response （SVR） respectively. Results There were no significant difference between the three groups in the rate of RVR, EVR and SVR （P 〉 0.05）. There was a higer rate of RVR,EVR and SVR in the genotype 2a group than the genotype lb group （P 〈0.05）. HCV genotype was the independent predictor＇（ OR = 12.78.95% , CI = 11.97-82.89, P = 0. 0075） of SVR. Conclusion There was a similar virological response between prolonged therapy of chronic hepatitis C with low-dose peginterferon alpha-2a and the standard dose and duration. The genotype was the independent predictors of SVR in peginterferon alpha-2a antiviral therapy of chronic hepatitis C.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2010年第2期142-144,共3页
Chinese Journal of Experimental and Clinical Virology
