摘要
目的:探讨Ki-67增殖抗原在乳腺浸润性导管癌组织中的表达及与临床病理特征、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(C-erbB-2)和抑癌基因p53的关系。方法:采用Elivison二步法进行免疫组化染色,检测102例单侧乳腺浸润性导管癌组织中Ki-67、ER、PR、C-erbB-2和p53的表达水平,并结合患者相关临床资料进行分析。结果:Ki-67高表达(≥14%)比例占82.4%(84/102)。不同分子亚型中,luminalA型Ki-67表达率最低,三阴性(导管)最高。Ki-67表达水平与单侧浸润性导管癌患者的淋巴结转移(χ2=5.007,P=0.025)、TNM分期(u=705.000,P=0.032)和组织分级(单侧Fisher:P=0.042)有明显的相关性,与患者的年龄(t=1.996,P=0.052)、肿块大小(u=859.000,P=0.502)和侵犯脉管情况(χc2=0.762,P=0.383)无明显的相关性。Ki-67表达水平与ER(r=-0.273,P=0.005)、PR(r=-0.332,P=0.001)表达程度呈负相关;与C-erbB-2(r=0.327,P=0.001)、p53(r=0.343,P=0.000)表达程度呈正相关。结论:Ki-67表达与目前乳腺癌分子分型相关,其高表达是预后不良因素。
OBJECTIVE： To explorer the relation between Ki-67 antigen expression and clinical parameters,pathological parameters,estrogen Receptor（ER）,progesterone receptor（PR）,Human Epidermal growth factor Receptor 2（C-erbB-2） and anti-oncogene p53 in invasive ductal carcinoma（IDC） of the breast.METHODS： Ki-67,ER,PR,c-erbB-2 and p53 were detected in 102 cases of IDC tissue with Elivision immunohistochemical technique.RESULTS： The proportion of high-expression for Ki-67 Antigen（≥14%） was 82.4%（84/102）.Among five different molecular subtypes,Ki-67 expression levle of luminal A was the lowest,and HER-2 type was the highest.No differences in age of the patients（t=1.996,P=0.052）,tumor size（u=859.000,P=0.502） and vascular invasion（χc2=0.762,P=0.383） were evident between Ki-67 high IDC and low,but significant differences in metastatic lymph nodes（χ2=5.007,P=0.025）,TNM staging（u=705.000,P=0.032） and histopathologic grade（one-side fisher： P=0.042）.Ki-67 expression levels were correlated negatively with ER（r=-0.273,P=0.005） and PR（r=-0.332,P=0.001） expression levels;Positively with C-erbB-2（r=0.327,P=0.001） and p53（r=0.343,P=0.000） expression levels.CONCLUSION： Ki-67 expression and the present breast cancer molecular subtypes are interrelated with one another,and its high expression is a prognosis mala signal.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第3期212-216,共5页
Chinese Journal of Cancer Prevention and Treatment
