摘要
目的研究Ki-67、p53蛋白在胃癌组织中的表达情况及临床意义。方法选择我院病理科胃癌组织标本60例,同时选择癌旁组织标本20例,应用免疫组化SP法检测Ki-67、p53蛋白的表达情况。结果 Ki-67、p53蛋白在胃癌组织中的阳性表达率高于癌旁组织,差异有统计学意义(P<0.05);Ki-67、p53蛋白的阳性表达率在有淋巴结转移、低度分化、浸润肌层及浆膜层的组织中高于无淋巴结转移、高、中度分化、浸润黏膜层及黏膜下层的组织,差异有统计学意义(P<0.05,P<0.01);Ki-67与p53蛋白在胃癌组织中的表达呈正相关(r=0.679,P<0.01)。结论 Ki-67、p53蛋白均参与胃癌的发生和发展,二者可作为判断胃癌恶性程度及评估预后的指标。
Objective To investigate the expression of Ki-67 and p53 in gastric carcinoma and their clinical significance.Methods Immunohistochemistry SP method was used to detect the expressions of Ki-67 and p53 protein in 60 cases of gastric carcinoma and 20 cases of normal gastric mucosa.Results The expressions of Ki-67 and p53 of the gastric mucosa were higher than normal gastric mucosa,and the differences were statistical significance（P0.05）.The expressions of Ki-67 and p53 in lymph node metastasis,poorly differentiated cancer tissues,as well as deep muscular layer and serous membrane groups invaded by the cancer were significantly higher than those in normal lymph nodes,high and moderated differentiated cancer tissues and non-invaded mucosa and submucosa（P0.05,P0.01）.The expression of Ki-67 was also highly correlated with the expression of p53（r=0.679,P0.01）.Conclusion Ki-67 and p53 both involve the development and progress of gastric carcinoma.They can be valuable biomarkers to determine the malignant degree of gastric carcinoma and to predict prognosis.
出处
《解放军医药杂志》
CAS
2012年第4期9-11,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
