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HLA-G与自身免疫病相关性研究进展 被引量：7

The relationship between HLA-G and autoimmune diseases
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摘要 非经典人类白细胞抗原G(human leukocyte antigen-G,HLA-G)是机体内一类重要的免疫调节分子,包括膜结合型HLA-G(mHLA-G)及可溶性HLA-G(sHLA-G)两种分子表达形式。HLA-G分子可通过与受体结合直接抑制多种免疫活性细胞的生物学功能,或通过诱导产生免疫调节细胞间接抑制机体的免疫应答。研究显示,HLA-G基因多态性及分子表达在母胎免疫、感染、自身免疫病及肿瘤的发生发展中均有重要意义。对HLA-G在自身免疫病中的作用作一综述。 Non-classical human leukocyte antigen-G, an important immune regulatory molecule, plays a critical role in various physiological and pathological situations. It contains two molecular forms, membrane-bound HLA-G （mHLA-G） and soluble HLA-G（sHLA-G）. Both mHLA-G and sHLA-G could directly inhibit biological functions of immune cells by binding to receptors, or indirectly inhibit the immune response by inducing regulatory cells. Previous studies have shown that both gene polymorphisms and the expression of HLA-G are associated with maternal-fetal immunity, infection, autoimmune disease and the development of tumor. In the present review, we discuss current findings on the function of HLA-G in autoimmune diseases.
作者 徐丹萍 林爱芬 颜卫华
机构地区 温州医学院附属浙江省台州医院中心实验室
出处 《生命科学》 CSCD 2012年第3期217-222,共6页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金项目(31170879 8110-2218)
关键词 HLA—G 基因多态性 自身免疫病 human leukocyte antigen-G gene polymorphisms autoimmune diseases
分类号 R392.1 [医药卫生—免疫学]
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参考文献33

  • 1Yan WH.HLA-G expression in cancers:potential role indiagnosis,prognosis and therapy.Endocr Metab ImmuneDisord Drug Targets,2011,11(1):76-89.
  • 2Yan WH.Human leukocyte antigen-G in cancer:are theyclinically relevant?Cancer Lett,2011,311(2):123-30.
  • 3Nakajima H,Asai A,Okada A,et al.Transcriptionalregulation of ILT family receptors.J Immunol,2003,171(12):6611-20.
  • 4Yan WH,Lin A,Li M,et al.Analysis of the 14 bpinsertion and deletion polymorphism in human leukocyteantigen-G gene in two Chinese ethnic populations.TissueAntigens,2008,71(3):227-33.
  • 5陈金宝,史磊,姚宇峰,史荔,于亮,林克勤,陶玉芬,易文,黄小琴,孙浩,褚嘉祐.云南傣族、汉族HLA-G基因14bp插入/缺失多态性研究[J].遗传,2010,32(6):577-582. 被引量：8
  • 6Gonzalez A,Alegre E,Torres MI,et al.Evaluation ofHLA-G5 plasmatic levels during pregnancy and relation-ship with the 14-bp polymorphism.Am J ReprodImmunol,2010,64(5):367-74.
  • 7Rizzo R,Hviid TV,Govoni M,et al.HLA-G genotype andHLA-G expression in systemic lupus erythematosus:HLA-G as a putative susceptibility gene in systemic lupuserythematosus.Tissue Antigens,2008,71(6):520-9.
  • 8Veit TD,Cordero EA,Mucenic T,et al.Association of theHLA-G 14 bp polymorphism with systemic lupus erythe-matosus.Lupus,2009,18(5):424-30.
  • 9Consiglio CR,Veit TD,Monticielo OA,et al.Associationof the HLA-G gene+3142C>G polymorphism withsystemic lupus erythematosus.Tissue Antigens,2011,77(6):540-5.
  • 10Rizzo R,Rubini M,Govoni M,et al.HLA-G 14-bppolymorphism regulates the methotrexate response inrheumatoid arthritis.Pharmacogenet Genomics,2006,16(9):615-23.

二级参考文献66

  • 1Rouas-Freiss N,Goncalves RM,Menier C,Dausset J,Carosella ED.Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis.Proc Natl Acad Sci USA,1997,94(21):11520-11525.
  • 2Rousseau P,Le Discorde M,Mouillot G,Marcou C,Carosella ED,Moreau P.The 14 bp deletion-insertion polymorphism in the 3' UT region of the HLA-G gene influences HLA-G mRNA stability.Hum Immunol,2003,64 (11):1005-1010.
  • 3Hylenius S,Andersen AM,Melbye M,Hviid TV.Association between HLA-G genotype and risk of pre-eclampsia:a case-control study using family triads.Mol Hum Reprod,2004,10(4):237-246.
  • 4Hviid TV,Hylenius S,Hoegh AM,Kruse C,Christiansen OB.HLA-G polymorphisms in couples with recurrent spontaneous abortions.Tissue Antigens,2002,60(2):122-132.
  • 5Rizzo R,Hviid TV,Govoni M,Padovan M,Rubini M,Melchiorri L,Stignani M,Carturan S,Grappa MT,Fotinidi M,Ferretti S,Voss A,Laustrup H,Junker P,Trotta F,Baricordi OR.HLA-G genotype and HLA-G expression in systemic lupus erythematosus:HLA-G as a putative susceptibility gene in systemic lupus erythematosus.Tissue Antigens,2008,71(6):520-529.
  • 6Lin A,Yan WH,Xu HH,Tang LJ,Chen XF,Zhu M,Zhou MY.14 bp deletion polymorphism in the HLA-G gene is a risk factor for idiopathic dilated cardiomyopathy in a Chinese Han population.Tissue Antigens,2007,70(5):427-431.
  • 7Fabris A,Catamo E,Segat L,Morgutti M,Arraes LC,de Lima-Filho JL,Crovella S.Association between HLA-G 3'UTR 14-bp polymorphism and HIV vertical transmission in Brazilian children.AIDS,2009,23(2):177-182.
  • 8Yao Y,Shi L,Matsushita M,Yu L,Lin K,Tao Y,Huang X,Yi W,Oka T,Tokunaga K,Chu J.Distribution of HLA-A,-B,-Cw,and -DRB1 alleles and haplotypes in an isolated Han population in Southwest China.Tissue Antigens,2009,73(6):561-568.
  • 9Yao Y,Shi L,Lin K,Yu L,Sun H,Huang X,Tao Y,Yi W,Liu S,Chu J.The association between HLA-A,-B alleles and major histocompatibility complex class I polymorphic Alu insertions in four populations in China.Tissue Antigens,2009,73(6):575-581.
  • 10Tripathi P,Abbas A,Naik S,Agrawal S.Role of 14-bp deletion in the HLA-G gene in the maintenance of pregnancy.Tissue Antigens,2004,64(6):706-710.

共引文献13

同被引文献89

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二级引证文献15

生命科学
2012年 第3期

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