摘要
人类白细胞抗原-G(human leukocyte antigen G,HLA-G)属于非经典HLA I类分子,是机体内重要的免疫耐受分子。正常生理条件下,HLA-G表达具有组织局限性。功能研究显示,HLA-G与表达在免疫细胞表面的受体结合直接发挥免疫抑制功能,或通过诱导产生调节性T细胞(regulatory T cells,Treg),或通过胞啃(trogocytosis)机制产生HLA-Gpos免疫细胞间接参与机体的免疫耐受。就HLA-G胞啃机制及其功能作一综述。
Human leukocyte antigen-G （HLA-G）, a non-classical HLA class I molecule, is an important immunotolerant factor. HLA-G expression is highly tissue-restricted in physiological conditions. HLA-G can directly inhibit the activation of a variety of immune cells by binding to receptors, or indirectly inhibit the immune response by inducing regulatory T cells or by producing HLA-Gp^s immune cells through trogocytosis. In the present review, we discussed current findings on the HLA-G acquisition through trogocytosis and its function.
出处
《生命科学》
CSCD
2013年第3期285-288,共4页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31170879
81102218)
关键词
HLA-G
胞啃
免疫细胞
human leukocyte antigen-G
trogocytosis
immune cells
