摘要
目的探讨原发性高血压和肾胜高血压患者血管紧张素Ⅱ2型受体基因A1675G单核苷酸多态性与高血压发生的关系。方法应用直接测序方法对80例原发性高血压、80例肾性高血压和40名正常人群中血管紧张素U2型受体基因作SNP分型。结果原发性高血压组A等位基因频率56．88％（91／160），对照组30．00％（24／80），差异有统计学意义（X^2=15．44，P〈0．001）；A等位基因频率与肾性高血压无关联E42．50％（68／160）与30．00％（24／80），X^2=3．52，P〉0．05）。基因型分析原发性高血压和肾性高血压差异均无统计学意义（P均〉0．05）。结论血管紧张素Ⅱ2型受体基因的A1675G单核苷酸多态性与原发性高血压发病有关。与肾性高血压无关。
Objective To study the relationship between angiotensin I1 type 2 receptor （AGTR2） gene single nucleotide polymorphisms and hypertension in patients with essential hypertension and renal hypertension. Methods Direct DNA sequencing was performed to detect the single nucleotide polymorphisms （SNP） in eighty patients with essential hypertension, eighty patients with renal hypertension and forty normal blood pressure controls. Results There was significant difference on A allele frequencies between essential hypertension group and control group （56. 88% [ 91/160 ] vs 30. 00% [ 24/80 ], X^2 = 15.44, P 〈 0. 001 ）. A allele frequency had no correlation with renal hypertension （ 42. 50% [ 68/160 ] vs 30. 00% [ 24/80 ], X^2 = 3.52,P 〉 0. 05 ）. There was no significant difference on SNP between essential hypertension group and renal hypertension group （ P 〉 0. 05 ）. Conclusion A1675G signal nueleotide polymorphisms of AGTR2 may be associated with the development of essential hyoertension , but has nothin~ to do with renal hvoertension.
出处
《中国综合临床》
2012年第4期351-353,共3页
Clinical Medicine of China
基金
南京军区医学科技创新课题（08MB129）
关键词
原发性高血压
肾性高血压
血管紧张素Ⅱ
受体
单核苷酸
多态性
Essential hypertension
Renal hypertension
Angiotensin 11
Receptor
Singlenucleotide polymorphism
