期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管损伤修复中血管紧张素Ⅱ2型受体与细胞凋亡的关系

暂未订购
导出
摘要 近来研究发现血管紧张素II2型受体(AT2R)在心血管方面的作用与1型受体(AT1R)完全相反,通过使AT2R的表达增加可以抑制血管平滑肌细胞的增生,并且可以促进细胞凋亡的发生,从而减轻血管内皮损伤后新生内膜的过度增生。本文综述血管内皮损伤后新生内膜形成中AT2R对细胞凋亡的影响及机制。
作者 苗莉 何国祥
机构地区 中国人民解放军第三军医大学西南医院心内科
出处 《国际心血管病杂志》 2007年第6期421-424,共4页 International Journal of Cardiovascular Disease
关键词 血管紧张素Ⅱ2型受体 血管修复 新生内膜 细胞凋亡
分类号 R543 [医药卫生—心血管疾病]
  • 相关文献

参考文献13

  • 1[1]Yagi S,Morita T,Katayama S.Combined treatment with an AT1 receptor blocker and angiotensin converting enzyme inhibitor has an additive effect on inhibiting neointima formation via improvement of nitric oxide production and suppression of oxidative stress[J].Hypertens Res,2004,27 (2):129-135.
  • 2[2]Maitland K,Bridges L,Davis WP,et al.Different effects of angiotensin receptor blockade on end-organ damage in saltdependent and salt-independent hypertension[J].Circulation,2006,114 (9):905-911.
  • 3[3]Suzuki J,Iwai M,Nakagami H,et al.Role of Angiotensin Ⅱ-Regulated apoptosis through distinct AT1 and AT2 receptors in neointimal formation[J].Circulation,2002,106(7):847-853.
  • 4[4]Durand E,Mallat Z,Addad F,et al.Time courses of apoptosis and cell proliferation and their relationship to arterial remodeling and restenosis after angioplasty in an atherosclerotic rabbit model[J].J Am Coll Cardiol,2002,39 (18):1680-1685.
  • 5[5]Lehtonen JY,Horiuchi M,Dzau VJ,et al.Ceramide as a second messenger for angiotensin Ⅱ type 2 receptor mediated apoptosis[J].Circulation,1997,96 (8S):554-555.
  • 6唐兵,何国祥,李德,黎军.大鼠血管紧张素Ⅱ2型受体基因转染对颈动脉球囊损伤后新生内膜形成的影响[J].中国介入心脏病学杂志,2005,13(2):108-110. 被引量：3
  • 7[7]Masaru Iwai,Rui Chen,Zhen Li,et al.Deletion of Angiotensin Ⅱ Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E-Null Mice[J].Circulation,2005,112 (11):1636-1643.
  • 8[8]Virna LS,Galina KS,Marco ALI,et al.Angiotensin Type 2 Receptor Is Expressed in Murine AtheroscleroticLesions and Modulates Lesion Evolution[J].Circulation,2005,112 (21):3328-3336.
  • 9[9]Jugdutt BI,Menon V.AT2R receptor and apoptosis during AT1 receptor blockade in reperfused myocardial infarction in the rat[J].Mol Cell Biochem,2004,262 (1-2):203-214.
  • 10景涛,何国祥,刘建平,王海东,冉擘力,王耿.血管紧张素Ⅱ2型受体基因可调控表达对体外培养血管平滑肌细胞中P21表达的影响[J].中国临床康复,2005,9(7):42-44. 被引量：1

二级参考文献11

  • 1Nheu T, He H, Hirokawa Y, et al. PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle 2004; 3 (1):71 -4.
  • 2Shoji T, Tanaka F, Takata T, et al. Clinical significance of p21 expression in non-small-cell lung cancer. J Clin Oncol 2002; 20( 18): 3865 - 71.
  • 3Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol 2002; 89 (2A): 3A - 9A.
  • 4Kubo A, Fukuda N, Teng J, et al. Angiotensin Ⅱ regulates the cell cycle of vascular smooth muscle cells from SHR. Am J Hypertens 2000; 13 (10): 1117 -24.
  • 5Tai XC.Nakagumi H,Iwai M,et al.Pivotal role of tyrosine phosphatase SHP-1 in AT2 receptor-mediated apoptosis in rat fetal vascular smooth muscle cell.Cardio Res,2001,49:863-871.
  • 6Kurisu S,Ozono R.Oschima T,et al.Cardiac angiotensin Ⅱ AT2 receptor activates the kinin/NO system and inbibits fibrosis.Hypertension,2003,41:99-107.
  • 7Matsubara H.Angiotensin Ⅱ type 2(AT2)receptor signal and cardiovascular action.Nippon Yakurigaku Zasshi,2002,119:99-102.
  • 8He TC,Zhou S.da Costa L,et al.A simplified system for generating recomblnat adenoviruses.Proc Natl Acad Sci USA,1998,95:2509-2514.
  • 9刘建平,何国祥,景涛,史光鉴,张小荣.血管紧张素Ⅱ2型受体转染表达对血管平滑肌细胞增殖及迁移的影响[J].高血压杂志,2001,9(2):127-130. 被引量：12
  • 10刘建平,何国祥,景涛.血管平滑肌细胞功能调节中血管紧张素1型受体表达和生物学作用的变化[J].中国临床康复,2004,8(6):1054-1056. 被引量：4

共引文献2

国际心血管病杂志
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部