摘要
目的研究血管紧张素Ⅱ-1型受体基因多态位点A1166C与原发性高血压的关系。方法采用聚合酶链反应技术(PCR)对48名40岁以上成人和39例原发性高血压患者血管紧张素Ⅱ-1型受体(AT1R)基因多态性进行检测。结果 AC基因型、C等位基因频率高血压组与健康人群对照组差别无统计学意义(χ2=0.026、0.023,P>0.05)。结论血管紧张素Ⅱ-1型受体基因可能与原发性高血压发病无关。
Objective To identify the association between gene polymorphism of A1166C angiotensin,type 1 receptor（AT1R）and essential hypertension（EH）.Methods AT1R gene polymorphism was determined by polymerase chain reaction（PCR） in 48 normal controls over aged 40 and 39 cases of EH.Results The AC genotype and C allele were not significantly different between the two groups（χ2=0.026,0.023,P0.05）.Conclusion The AT1R polymorphism might not be associated with EH.
出处
《医学研究与教育》
CAS
2012年第6期13-16,共4页
Medical Research and Education
