摘要
大鼠腹腔注射小剂量Z_n^(2+)或内毒素后,肝脏金属硫蛋白(MT)含量较对照动物分别增加了90.3和62.6倍,心脏MT含量增加4.1和3.2倍。诱导处理显著增强大鼠对内毒素休克(内毒素20mg/kg iv)的耐受性:维持动物血压和心功能于较好水平,抑制血浆组织蛋白酶活性和脂质过氧化物MDA的增加,显著提高动物存活率。休克动物肝脏MT含量与MDA含量呈负相关关系(r=-0.732,P<0.001)。实验结果表明,MT参与机体抵抗内毒素休克的防御机制。
Under the condition of severe stress, there is an enhancement of metallothionein (MT) synthesis in the body, however, the biological effect of MT in diseases is yet unclear. This experiment was performed on the endotoxic shock rats, The MT synthesis of which had been induced by intraperito-neal preinjection of either Zn2+ or endotoxin at low doses. The results showed that the induction of MT synthesis elevated resistance to endotoxin shock: blood pressure and cardiac function of the animals were kept at higher levels, increases of plasma cathepsin D and plasma MDA were inhibited, and survival rate of the shocked animals were significantly elevated, (compared with control rats, P<0.05 or P<0.01). There was a negative correlation between MT content and MDA content in shocked rat livers (r= -0.732, p<0.001). The results suggest that MT is implicated in the defence function of the organism during endotoxin shock.
出处
《北京医科大学学报》
CSCD
1989年第2期109-112,共4页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
