摘要
目的观察利尿剂联合血管紧张素Ⅱ受体拮抗剂治疗肾病综合征合并高血压的疗效。方法将72例肾病综合征合并高血压患者随机分为3组,A组给予血管紧张素Ⅱ受体拮抗剂(ARB)治疗,B组给予利尿剂治疗,C组给予ARB联合利尿剂治疗,连续用药3个月,并监测治疗前后血压、肾功能、尿蛋白排泄率。结果 3组治疗后血压、BUN、Scr和尿蛋白排泄率显著改善,与治疗前比较有显著性差异(P<0.05);且C组改善血压、BUN、Scr优于A组和B组(P<0.05);A组和C组治疗后尿蛋白排泄率改善优于B组(P<0.05)。结论利尿剂联合血管紧张素Ⅱ受体拮抗剂治疗肾病综合征合并高血压安全有效,其疗效优于单独用药。
Objective To observe the therapeutic effect of Nephrotic syndrome with Hypertension by diuretic Combined with Angiotensin Ⅱ receptor antagonist.Methods 72patients were randomly divided into three groups.Patients in the A group were treated with Angiotensin Ⅱ receptor antagonist,Patients in the A group were treated with diuretic,while patients in C group treated with ARB and diuretic for 3months.Blood pressure,renal function,Urine protein excretion were detected.Results The three groups after treatment significantly improved blood pressure 、 BUN 、 Scr and Urine protein excretion,compared with the pre-treatment was significantly different（P0.05）,and the C group was better than the A and B group in blood pressure,BUN,Scr（P0.05）;the A and C group was better than B group in Urine protein excretion.Conclusion Diuretic Combined with Angiotensin Ⅱ receptor antagonist was efficient and safe for the treatment of Nephrotic syndrome with Hypertension,which was more efficient than medication alone.
出处
《西部医学》
2012年第2期284-285,288,共3页
Medical Journal of West China
