期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-17与感染性疾病的研究进展 被引量：6

原文传递
导出
摘要 白介素17(IL-17)是一个具有强大促炎作用的细胞因子,其生物学活性至今仍未被完全明确。先前对IL-17的研究主要集中于其在肿瘤、自身免疫性疾病中的致病作用,近几年来,许多研究报道IL-17能够通过招募和活化中性粒细胞、促进促炎细胞因子、趋化因子及抗体的生成以及激活T细胞等功能,对细菌、病毒、真菌等病原体发挥重要的抗感染作用。本文就近年来关于IL-17与感染性疾病的关系做一综述。
作者 刘爱妮 谭晓冬
机构地区 山东大学医学院附属山东省千佛山医院儿科
出处 《现代免疫学》 CAS CSCD 北大核心 2012年第1期72-75,共4页 Current Immunology
基金 山东省自然科学基金资助项目(ZR2010HL013)
关键词 细胞因子 IL-17 感染性疾病 感染免疫
分类号 R392.7 [医药卫生—免疫学]
  • 相关文献

参考文献22

  • 1Onishi RM,Gaffen SL.Interleukin-17and its target genes:mechanisms of interleukin-17function in disease[J].Immunity,2010,129:311-321.
  • 2Bettelli E,Carrier Y,Gao W,et al.Reciprocal developmen-tal pathways for the generation of pathogenic effecter THl7 and regulation T cells[J].Nature,2006,441:235-238.
  • 3Marks BR,Craft J.Barrier immunity and IL-17[J].Semin Immunol,2009,21:164-171.
  • 4Liang SC,Tan XY,Luxenberg DP,et al.Interleukin(IL)-22and IL-17are coexpressed by Th17cells and cooperatively enhance expression of antimicrobial peptides[J].J Exp Med,2006,203:2271-2279.
  • 5LeGrand A,Fermor B,Fink C,et al.Interleukin-1,Tumor necrosis factorα,and interleukin-17synergistically up-regulate nitric oxide and prostaglandin E2production in ex-plants of human osteoarthritis knee menisci[J].Arthritis Rheum,2001,44:2078-2083.
  • 6Ye P,Rodriguez FH,Kanaly S,et al.Requirement of inter-leukin17receptor signaling for lung CXC chemokine and granulocyte colony stimulating factor expression,neutrophil recruitment,and host defense[J].J Exp Med,2001,194:519-527.
  • 7Shiomi S,Toriie A,Imamura S,et al.IL-17is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model[J].Helicobacter,2008,13:518-524.
  • 8Schulz SM,Kohler G,Holscher C,et al.IL-17Ais produced by Th17,γδT cells and other CD4-lymphocytes during infec-tion with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance[J].Int Immunol,2008,20:1129-1238.
  • 9Khader SA,Cooper AM.IL-23and IL-17in tuberculosis[J].Cytokine,2008,41:79-83.
  • 10项杰,章晓联,席淑红,李虹泽,胡加炎.结核病人血清IL-17、TNF-α、IFN-γ的检测及其免疫学意义[J].数理医药学杂志,2009,22(2):149-151. 被引量：15

二级参考文献44

  • 1Yew WW, Leung CC. Update in tuberculosis 2008. Am J Respir Crit Care Med, 2009,179(5) :337-343.
  • 2Laan M, Palmberg L, Larsson K, et al. Free soluble interleukin -17 proteinduring severe inflammation in human airways. Eur Respir J, 2002,19(3) :534-537.
  • 3Ye P,Garvey PB,Zhang P,et al. interleukin -17 and lung host defenseagainst Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol, 2001,25 (3) : 335-340.
  • 4Ye P,Rodriguez H-1, Kanaly S, et al. Requirement of interleukin - 17 receptorsignaling for lung CXC chemokine and granulecyte colony stimulatingfactor expression, neutrophil recruitment, and host defense. J Exp Med, 2001,194(4) : 519-527.
  • 5Veenstra H, Crous I, Brahmbhatt S, et al. Changes in the kinetics of intracellular IFN-gamma production in TB patients during treatment. Clin Immunol. 2007, 124(3):336-344.
  • 6Millington KA, Innes JA, Hackforth S , et al, Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J Immunol. 2007, 15;178 (8) : 5217-5226.
  • 7Mansouri D, Adimi P, Mirsaeidi M, et al, Inherited disorders of theIL-12-IFN-gamma axis in patients with disseminated BCG infection. Eur J Pediatr, 2005,164(12) : 753-757.
  • 8Ates O, Musellim B, Ongen G, et al. Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J Clin Immunol, 2008,28(3) :232-236.
  • 9Thacker TC, Palmer MV, Waters WR. et al. Associations between cytokine gene expression and pathology in Myeobaeterium bovis infected cattle. Vet Immunol Immunopathol. 2007, 15; 119 (3-4):204-213.
  • 10Cooper AM, Khader SA. The role of cytokines in the initiation, expansion, and control of cellular immunity to tuberculosis. Immunol Rev, 2008,226 : 191-204.

共引文献26

同被引文献57

引证文献6

二级引证文献27

现代免疫学
2012年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部