摘要
利用细胞微管吸吮实验系统对正常及活化状态下中性粒细胞(PMN)的变形能力及其改变作单细胞定量研究,结果显示PMN的变形能力在内毒素刺激活化条件下迅速降低,1小时内降至最低,以后随刺激时程的延长,PMN仍维持于该变形能力降低状态。活化PMN变形能力显著降低有助于PMN在脏器组织的滞留,从而发挥消灭病原微生物及引起炎性损伤的作用。
Monocellular quantitative study on the deformabllity of normal and activated polymorphonu-clear neutrophil(PMN) was performed by micromanipulation technique. The results showed that treatment of PMN with endotoxin caused a rapid decrease in cell deformobility. This change reached to minimum within 1 hour and maintained in this condition with the prolongation of exposure to endotoxin. The decreased de-formability of activated PMN is helpful for PMN sequestration in tissue so as to destroy the infectious microorganisms and mediate the inflammatory tissue damages.
关键词
中性粒细胞
变形能力
单细胞定量
Neutrophils Deformability Micromanipulation technique
