摘要
目的观察部芩片治疗耐多药肺结核患者的临床疗效及机制。方法将52例耐多药肺结核患者随机分为治疗组17例、微卡组17例、对照组18例,分别给予西药基础治疗加部芩片、西药基础治疗加微卡注射液及西药基础治疗,疗程6个月,观察各组治疗后临床疗效,并检测其治疗前、治疗后2个月、治疗后6个月白细胞介素12(IL-12)、干扰素(IFN-γ)含量。结果治疗后2个月治疗组、微卡组、对照组的有效率分别为82.35%、52.94%和41.18%,治疗组有效率明显高于对照组(P<0.05),微卡组和对照组比较差异无统计学意义(P>0.05)。治疗后6个月治疗组、微卡组、对照组的有效率分别为88.24%、82.35%和70.59%,与对照组比较,治疗组和微卡组有效率均明显升高(P<0.05);与治疗后2个月比较,治疗后6个月微卡组和对照组有效率均明显升高(P<0.05),但治疗组差异无统计学意义(P>0.05)。与治疗前比较,治疗后2个月各组IL-12及IFN-γ含量差异均无统计学意义(P>0.05)。与治疗前比较,治疗后6个月治疗组及微卡组IL-12含量明显升高,差异有统计学意义(P<0.01),各组IFN-γ含量明显升高(P<0.05)。治疗后6个月治疗组和微卡组IL-12及IFN-γ含量明显高于对照组(P<0.05或P<0.01)。结论部芩片可以明显提高耐多药肺结核患者的临床疗效;提高耐多药肺结核患者IL-12和IFN-γ含量,达到治疗耐多药肺结核的作用。
ABSTRACT Objective To study the therapeutic effect of Buqin Tablet [Tablet of Baibu （Radix Stemonae） and Huangqin （Radix Scutellariae）] for multidrug-resistatat tuberculosis （MI）R-TB） and its mechanism. Methods Fifty-two cases of MDR- TB were randomized into treatment group （17 cases）, Vaccae group （17 case） and control group （18 cases）. All groups were given anti-tuberculosis drugs. Buqin Tablet and Vaccae injection was added respectively in the treatment group and Vaccae group. The treatment lasted for 6 months. The therapeutic effect was observed and the contents of interleukin-12 （IL-12） andinterferon-a （IFN-ct） were detected before and after 2 months and 6 months of treatment. Results After 2 months, the effec- tive rate of the treatment group, Vaccae group and control group was 82. 350/00 （14/17）, 52.94% （9/17） and 41.18% （7/17） respectively. The effective rate of the treatment group was superior to that of control group （P〉0.05）. There was no signifi- cant difference between the Vaccae group and control group （P〉0.05）. After 6 months, the effective rate of the treatment group, Vaccae group and control group was 88.24% （15/17）, 82.35% （14/17） and 70.59% （12/17） respectively. Compa- ring with the control group, the effective rates of the treatment group and Vaccae group increased significantly （P〈0.05）. Theeffective rates of the control group and Vaccae group increased significantly after 6 months of treatment as compared with those after 2 months of treatment （P〈0. 05）. There was no significant difference in the treatment group between different treatment times （P〉0.05）. After 2 months, the contents of IL-12 and IFN-u increased in the treatment group and Vaccae group without statistical significance （P〉0.05）. After 6 months, the contents of IL-12 in all the groups increased significantly, especially in the treatment group and Vaccae group （P〈0.01）. The contents of IFN-a increased significantly in all the groups （P〈0.05）. Comparing with the control group, the contents of IL-12 and IFN-ct increased in the treatment group and Vaccae group after 2 months of treatment, especially after 6 months of treatment （P〈0.05 or P〈0.01）. Comparing with the treatment group, the contents of IL-12 and IFN-a increased in the Vaccae group both after 2 months and 6 months of treatment without statistical significance （P〉0.05）. Conclusion Buqin Tablet is effective for MDR-TB by increasing the contents of IL-12 and IFN-a.
出处
《中医杂志》
CSCD
北大核心
2012年第8期669-672,共4页
Journal of Traditional Chinese Medicine
基金
杭州市科学技术局研究项目(20080333Q24)
关键词
部芩片
耐多药肺结核
白细胞介素12
干扰素
Buqin Tablet[Tablet of Baibu （Radix Stemonae） and Huangqin （Radix Scutellariae）]
multidrug-resistant tuber-culosis~ interleukin-12~ interferon
