摘要
目的探讨高胆红素血症(高胆)早产儿血清胰岛素样生长因子-1(IGF-1)水平的变化及其临床意义。方法应用电化学发光免疫法检测64例高胆早产儿(实验组)和20例非高胆早产儿(对照组)血清IGF-1、神经元烯醇化酶(NSE)水平,同步测定其血清总胆红素(TSB)水平,并比较组间IGF-1、NSE、TSB水平的差异及其相关性。高胆组按TSB 170～256μmol.L-1,257～342μmol.L-1,>342μmol.L-1分为轻、中、重3组。结果轻、中、重高胆早产儿血清IGF-1水平分别为(25.38±5.42)μg.L-1、(21.77±8.65)μg.L-1、(18.34±4.05)μg.L-1,较对照组[(27.14±3.72)μg.L-1]明显降低,轻、中、重高胆组间IGF-1水平存在统计学差异(Pa<0.01),其值随着胆红素水平变化而变化;高胆组NSE水平分别为(25.01±2.26)μg.L-1、(30.45±2.74)μg.L-1、(33.76±5.02)μg.L-1,明显高于对照组[(11.14±4.68)μg.L-1](P<0.01),各组间差异均有统计学意义(Pa<0.01);血清IGF-1水平与TSB、NSE均呈负相关(r=-0.562、-0.503,Pa<0.01)。结论 IGF-1与高胆早产儿的预后密切相关,可作为判断高胆早产儿是否存在脑损伤的生化指标之一。
Objective To study the change of serum insulin-like growth factor-1（IGF-1） in premature infants with hyperbilirubinemia and its clinical significance. Methods Serum levels of IGF-1 and neuron-specific enolase（NSE） were measured by electric-chemiluminescent immunoa-ssay,and total serum bilirubin（TSB） was detected in 64 premature infants with hyperbilirubinemia（experiment group） and 20 premature infants without hyperbilirubinemia（control group）,respectively.The levels of TSB,170-256 μmol·L-1 were defined as mild hyperbilirubinemia group,257-342 μmol·L-1 as moderate group,and342 μmol·L-1 as severe group. Results 1.The levels of IGF-1 in serum in hyperbilirubinemia groups[（25.38±5.42） μg·L-1,（21.77±8.65） μg·L-1,（18.34±4.05）μg·L-1] were decreased obviously than that in control group[（27.14±3.72） μg·L-1]（P0.01） and there were significant differences among the experiment groups（Pa0.01）.2.The mean NSE in experiment groups [（25.01±2.26） μg·L-1,（30.45±2.74） μg·L-1,（33.76±5.02） μg·L-1] were significantly higher than that in control group[（11.14±4.68） μg·L-1],and there were significant differences among experiment groups（Pa0.01）.3.Serum IGF-1 levels were negatively correlated to NSE and TSB（r=-0.562,-0.503,Pa0.01）. Conclusions IGF-1 may be closely correlated to the prognosis of premature infants with hyperbilirubinemia.IGF-1 levels can act as the biochemical indicator for bilirubin-induced brain damage in premature infants.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2012年第2期110-111,115,共3页
Journal of Applied Clinical Pediatrics
