摘要
目的 探讨新生儿缺氧缺血性脑病的发病机制 ,寻求早期诊断的指标。方法 临床研究的指标是按临床症状分组 ,测定缺氧缺血性脑病新生儿血浆中血小板活化因子 (PAF)和血清中神经元烯醇化酶 (NSE)水平的变化。结果 新生儿缺氧缺血性脑病轻、中、重度患儿血清NSE浓度分别为 (1 9±5 7)、(3 9± 1 6 )、(83± 2 1 ) μg·L- 1 (P <0 0 1 ) ;血浆PAF分别为 (2 0± 7 6 )、(2 9± 6 4)、(5 6± 8) μmol·L- 1(P <0 0 5或P <0 0 1 )。结论 研究发现新生儿缺氧缺血性脑病的致病因子之一是PAF ,缺氧缺血性脑病患儿血浆中PAF增高 ,其水平与NHIE的严重程度有关。PAF参与了NHIE的发病过程。NHIE患儿血清NSE增高 ,其水平与本病的严重程度有关 ,故认为NSE可作为该病的早期诊断的血清学指标。
Objective To search for methods of early diagnosis and pathogenesis of neonatal hypoxic ischemic encephalopathy(NHIE).Methods We have made clinical specimens grouped research on neonatal hypoxic-ischemic encephalopathy and examined the platelet activating factor concentration and neuron specific enolase concentration in clinical hypoxic-ischemic newborn specimens blood.Results The serum NSE in neonatal HIE on minor, middle, heavy degree was (19±5.7),(39±16),(83±21) μg·L -1(P<0.01)l respectively(P<0.01);the plasma PAF in neonatal HIE on minor, middle, heavy degree was (20±7.6),(29±6.4),(56±8) μmol·L -1(P<0.05 or P<0.01).Conclusion We concluded that platelet activating factor (PAF) is one of pathogenic factor in HIE.Neuron specific enolase(NSE) may be an early prediction factor of hypoxic ischemic encephalopathy.
出处
《兰州医学院学报》
2003年第3期27-29,共3页
Journal of Lanzhou Medical College
