摘要
目的探讨高胆红素血症新生儿血清神经元特异性烯醇化酶(NSE)和新生儿行为神经测定(NBNA)的变化、两者的相关性及其临床意义。方法应用酶联免疫吸附法检测42例高胆红素血症新生儿和29例正常新生儿血清中NSE浓度,同步测定血清总胆红素(TSB)、白蛋白含量,计算胆红素-白蛋白比值(B/A),并行新生儿NBNA评分。高胆组按TSB≥342μmol/L和171～342μmol/L分为实验组a和实验组b,对照组TSB<85.5μmol/L,结果两实验组血清NSE浓度均较对照组显著升高(P<0.01),两实验组间NSE浓度差异无显著性(P>0.05)。两实验组NBNA评分值均明显低于对照组(P<0.01),两实验组间差异无显著性(P>0.05)。血清NSE浓度与NBNA评分均呈显著性负相关(P<0.01)。结论血清NSE测定比TSB、B/A值能更早期预测新生儿胆红素脑损伤患病风险。
Objectives To explore the potential role of serum levels of neuron specific enolase （NSE） in full-term newborns with hyperbilirubinemia. Methods Serum levels of NSE by ELISA method,total serum bilirubin （TSB）,albumin and bilirubin/albumin （B/A） ratio were detected in 42 full-term newborn infants with hyperbilirubinemia and 29 normal full-term newborn infants,respectively. The level of TSB ≥342μmol/L were defined as group A （31 cases）,171- 342 μmol/L as group B （29 cases）,and 29 normal newborn infants whose TSB level less than 85.5 μ mol/L were as group C （29 cases）. Neonatal behavioral neurological assessment （NBNA） was undertaken in all three groups on the same day after blood sampling and on the 28 days old,respectively. Results （ 1 ） Serum levels of NSE in groups A and B were significantly higher than that in group C,while no significant difference in serum level of NSE was observed between group A and group B. （2） The mean NBNA score in groups A and B were significantly lower than that in group C,and also no significant difference was found between group A and group B. （3） Serum NSE levels were inversely correlated to NBNA score. Conclusions Comparing to serum TSB and B/A, serum NSE can be more helpful for predicting bilirubin-related early brain damage in term newborn infants with hyperbilirubinemia.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2006年第9期737-740,共4页
Journal of Clinical Pediatrics
基金
云南省卫生厅科研基金(No:M990149)
