摘要
【目的】观察应用卡维地洛对慢性心力衰竭患者疗效和对血浆脑钠肽(brain natriuretic peptide,BNP)、C反应蛋白(C-reactive protein,CRP)的影响。【方法】慢性心力衰竭患者60例,随机分为常规治疗组和卡维地洛治疗组各30例,常规治疗组用血管紧张素转化酶抑制药、利尿药和地高辛,卡维地洛治疗组在常规治疗药物的基础上加用卡维地洛,疗程12周。观察治疗效果并测定治疗前后左心室射血分数(left ventric-ular ejection fraction,LVFF)、左心室舒张末期内径(left ventricular end-diastolic dimension,LVEDd)、血浆BNP和CRP水平。【结果】治疗12周后,卡维地洛治疗组总有效率高于常规治疗组(P<0.05),卡维地洛治疗组LVFF、LVEDd、BNP、CRP与常规治疗组比较,差异均有统计学意义(P<0.05)。【结论】卡维地洛治疗慢性心力衰竭效果显著,可降低血浆中BNP和CRP水平,改善心功能。
[Objective]To observe the efficacy of carvedilol for the treatment of chronic heart failure（CHF） and its effect on plasma brain natriuretic peptide（BNP） and C-reactive protein（CRP）. [Methods] A total of 60 patients with CHF were randomly divided into two groups： the conventional group（with digoxin, diuretics and ACEI, n = 30）and the Carvedilol group（with carvedilol in addition to conventional therapy, n = 30）. The curative effect was observed after12-week treatment. Plasma BNP and CRP concentrations, left ventricular ejection fraction （LVEF）and left ventricular internal dimension at end-diastole（LVEDd）were measured before and after treatment. [Results]After 12-week treatment, there was an improvement of cardiac function in two groups. The total efficacy rate of the carvedilol group was higher than that of the conventional group（ P 〈0.05）. There were significant differences in LVFF, LVEDd, BNP and CRP between carvedilol group and conventional group （ P 〈0.05）. [Conclusion] Better curative effect will be achieved on patients with CHF who take carvedilol in addition than those who only take digoxin, diuretics and ACEI. Carvedilol can decrease plasma BNP and CRP concentrations and improve cardiac function.
出处
《医学临床研究》
CAS
2008年第7期1177-1179,共3页
Journal of Clinical Research
