摘要
目的:探讨凋亡抑制蛋白Livin和核转录因子NF-κBp65在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法:应用免疫组织化学方法检测40例NSCLC组织中Livin、NF-κBp65因子表达情况。结果:肺癌组织标本中,Livin与NF-κBp65的阳性表达率分别为70.4%、76.6%。Livin高表达与肺癌病理类型及有无淋巴结转移相关(P<0.05),NF-κBp65高表达与肺癌淋巴结转移及分化程度相关(P<0.05),Livin、NF-κBp65蛋白的表达之间存在显著正相关(r=0.265,P<0.05)。结论:NSCLC中存在Livin、NF-κBp65蛋白的高表达。NSCLC组织中Livin与NF-κBp65表达的上调,对肿瘤的发生、发展起着重要作用。
Objective： To investigate the expression and clinical significance of livin, NF-κBp65 protein in non--small cell lung cancer（NSCLC）. Methods： The expression of livin and NF-κBp65 was detected by immunohistochemical SP method in 40 cases of NSCLC. Results： The positive rates of livin and NF-κBp65 were 70. 4% and 76.6% in lung cancer specimens. The livin expression level was positively correlated with pathologic type and lymphnoid metastasis （P 〈0.05）, and NF-κBp65 was correlated with lymphnoid metastasis and TNM （P〈0.05）. There was a significant correlation between the expression of livin and the expression of NF -κBp65 in lung cancer （r = 0. 265,P 〈 0.05）. Conclusion： The livin and NF-κBp65 proteins show overexpression in NSCLC. The up--regulated expression of livin and NF-κBp65 in NSCLC plays a vital rote in progression of tumor.
出处
《黑龙江医药科学》
2011年第6期15-16,17,共3页
Heilongjiang Medicine and Pharmacy
