摘要
目的:探讨凋亡抑制因子Livin和凋亡促进因子Smac在人乳腺癌组织中的表达及相关性,分析其与乳腺癌转移复发的关系。方法:应用免疫组织化学SP法检测80例乳腺癌组织和相应的癌旁组织中Livin和Smac蛋白的表达情况。结果:80例乳腺癌组织中Livin蛋白表达的阳性率为63.75%(51/80),显著高于相应的癌旁组织的50.00%(40/80),P=0.003;乳腺癌组织中Smac表达为42.50%(34/80),显著低于癌旁组织的72.50%(58/80),P=0.000。两者的表达与组织学分级、肿瘤大小、腋窝淋巴结转移、术后复发及c-erbB-2表达密切相关,P<0.05。Livin和Smac的表达呈显著负相关,γ=-0.299,P=0.007。结论:Livin的高表达及Smac的失活可能在乳腺癌的发生、发展中起着重要作用。
OBJECTIVE：To investigate the expressions of Livin and Smac in breast carcer and their correlation with metastasis and recurrence. METHODS：Immunohistochemisty was employed to determine the expressions of Livin and Smac in 80 breast carcinomas and paired adjacent breast tissues. RESULTS：Livin was overexpressed in breast cancers （63.75%,51/80） compared with the paired adjacent breast tissues （50.00%,40/80） （P=0.003）and Smac was significantly lower in breast cancer （42.50%,34/80） compared with the paired adjacent breast tissues （72.50%,58/80）（P=0.000）. The protein expressions of Livin and Smac were significantly correlated with the histological grade,diameter of tumor,axillary lymph node metastasis,recurrence of tumor and expression of c-erbB-2 （P0.05）. There was a significantly negative relationship between Livin and Smac （γ=-0.299,P=0.007）. CONCLUSION：The inactivation of Smac and overexpression of Livin proteins might enhance the tumour cell proliferation and malignance and play an important role in progress of human breast cancer.
出处
《中华肿瘤防治杂志》
CAS
2009年第24期1925-1927,共3页
Chinese Journal of Cancer Prevention and Treatment
