摘要
目的 肺癌日益威胁着人们的健康。目前认为肺癌的发生是由于各种有害因素作用下机体免疫功能失调所致,而细胞因子是调节机体免疫功能的重要因素,可能在肺癌的发病机制中起着某种作用。本研究目的是为了探讨IL-2、IL-6、IL-8在肺癌发病中的作用。方法 用酶联免疫吸附法(ELISA)测定了21例非小细胞肺癌(NSCLC)、17例小细胞肺癌(SCLC)及10例健康人血清IL-2、IL-6、IL-8水平,统计学处理用两样本均数的t检验。结果 SCLC组血清IL-2、IL-6、IL-8水平分别为20459±3296ng/L,6149±2793ng/L,10920±3220ng/L,NSCLC组血清IL-2、IL-6、IL-8水平分别为20946±3298ng/L,6096±2313ng/L,11294±3354ng/L,而正常对照组它们分别为25745±2993ng/L,8011±1110ng/L,7332±703ng/L。结果显示,两组病人血清IL-2、IL-6水平明显低于正常对照组(SCLC组IL-2,t=383,P<001;IL-6,t=205,P<005;NSCLC组IL-2,t=354,P<001;IL-6,t=239,P<005),而这两组病人血清IL-8水平明显高于正常对照组(SCLC组t=344,P<001;NSCLC组t=365,P<001)。而在两组病人比较,各指标差异均无显著性(IL-2,t=035,P>005;IL-6,t=001,P>005;IL-8,t=027,P>005)。结论 肺癌患者IL-2、IL-6水平降低,而IL-8水平升高。
Objective Lung cancer harms our health increasingly, lung cancer is thought to be due to a series of harmful factors, These factors bring about the imbalance of humanbeing's immune system. Interleukins are important factors of adjusting the immune functions They perhaps play certain role in the pathogenesis of lung cancer. Our purpose is to study the role of IL-2,IL-6,IL-8 in lung cancer's pathogenesis.Methods We have measured serum IL-2,IL-6,IL-8 in 21 cases of non small cell lung cancer (NSCLC)、17 cases of small cell lung cancer (SCLC) and 10 health controlls with ELISA method.The static management was adopted with T test of two sample-means.Results The serum IL-2,IL-6,IL-8 levels in the SCLC class were 204 59±32 96 ng/L,61 49±27 93 ng/L,109 20±32 20 ng/L,respectively. And those in the NSCLC class were 209 46±32 98 ng/L,60 96±23 13 ng/L,112 94±33 54 ng/L,respectively. Those in the healty controls were 257 45±29 93 ng/L,80 11±11 10 ng/L,73 32±7 03 ng/L respectively. The results show that serum IL-2,IL-6 levels in these two class patients were significantly lower than those in health subjects (SCLC class:IL-2, t =3 83, P <0 01;IL-6, t =2 05, P <0 05;NSCLC class:IL-2, t =3 54, P <0 01;IL-6, t =2 39, P <0 05), and serum IL-8 levels in these two class patients were significantly higher than those in heatly subjects (SCLC class: t =3 44, P <0 01;NSCLC class: t =3 65, P <0 01). There was no difference in these two class pstients(IL-2, t =0 35, P >0 05;IL-6, t =0 01, P >0 05;IL-8, t =0 27, P >0 05).Conclusions There were lower serun IL-2,IL-6 levels and higher serum IL-8 levels in lung cancer patients. It impiled that there were similar immune abnormalities in various tissue types of lung cancer, these cytokins may play certain role in the pathogenesis of this disease. It suggests that rectifing these immune abnormality wouold be an important method in lung cancer treatment.
出处
《河南肿瘤学杂志》
2000年第1期15-16,共2页
Henan Journal of Oncology
