摘要
为了解双黄连口服液在使用过程中的安全性,参照《兽药注册资料汇编》中兽药急性毒性试验指导原则的要求,选用小白鼠进行急性毒性试验。小白鼠的最小致死量、半数致死量测定结果显示:双黄连口服液对小白鼠最小致死量范围为49.2～60.8 g/kg,相当于禽临床用量的111.8～138.2倍,说明双黄连口服液临床应用具有一定的安全性。
In order to observe the applied reliability of Shuanghuanglian oral liquid, the experiment was conducted in accordance with acute toxicity requirements in compilation of veterinary drug registration data. The acute toxicity of Shuanghuanglian oral liquid was studied by selecting mouse in this Shuanghuanglian oral liquid was demonstrated by the minimal lethal dose and the showed that 138.2 times experiment, the toxicity of LD50 of mouse. The results the minimal lethal dose ranged between 49.2 and 60.8 g/kg, which was equivalent to from 111.8 to of daily dosage of poultry. Shuanghuanglian oral liquid was relatively safe in clinical application.
出处
《中国兽药杂志》
2011年第12期29-30,52,共3页
Chinese Journal of Veterinary Drug
关键词
双黄连口服液
小鼠
急性毒性
Shuanghuanglian oral liquid
mouse
acute toxicity
