摘要
目的观察黄芩苷胶囊灌胃1日后产生的急性毒性反应和死亡情况,以评价其安全性。方法将黄芩苷胶囊的内容物黄芩苷粉以最大浓度给ICR小鼠灌胃给药,小鼠没有出现死亡,未测出LD50,故测其最大给药量。结果黄芩苷粉最大给药量为15g/kg。结论黄芩苷胶囊具有较好的安全性。
Objective To observe the acute toxic reaction and death of mice one day after intragastric administration of Baicalin cap- sule so as to appraise its safety. Methods The ICR mice were intragastrically administered with Baicalin powder in capsule at maximum concentration. There was no death of mice tound and no LD50 detected after administration. Hence the maximum dosage was identified. Results The maximum dosage of Baicalin powder is 15g/kg. Conclusions The Baicalin capsule is relatively safe.
出处
《医学研究杂志》
2006年第9期16-19,共4页
Journal of Medical Research
基金
浙江省中医药卫生科技计划项目(2003C130)
杭州市重大科技发展计划项目(2003123B19)
杭州市医药卫生重点项目(2004Z006)
杭州市131优秀中青年科技培养人才项目资助
关键词
黄芩苷
急性毒性
灌胃给药
小鼠
Baicalin
Acute toxicity
Intragastric administration
Mice
