摘要
目的观察立体定向放射治疗(SBRT)非小细胞肺癌的近期疗效和放射副反应。方法 112例非小细胞肺癌患者行伽玛刀放疗,50%的处方剂量线完全覆盖PTV,60%～70%剂量线包裹95%以上GTV,照射剂量以50%剂量线作为处方剂量,3～12 Gy/次,总剂量40～60 Gy,1～3周完成治疗。结果治疗后3～16个月所有患者得到随访,中位随访时间11个月,其中完全缓解(CR)率29.5%(33/112),部分缓解(PR)率为60.7%(68/112),总有效率为90.2%(101/112)。6个月和1年的局控率分别为98.8%(80/81)、92.3%(36/39),生存率分别为100%(81/81)、94.9%(37/39);放射性肺炎为其主要并发症,发生率为9.8%(11/112)。结论 LUNATM-260型伽玛刀作为1种新的SBRT设备,能够有效地提高非小细胞肺癌的局部控制率和生存率,且并发症发生率低。
Objective To investigate the short-term therapeutic effectiveness and side effect of stereotactic body radiotherapy（SBRT） in patients with non-small cell lung cancer（NSCLC）.Methods 112 patients with NSCLC were treated by LUNATM-260 Gamma Knife.The PTV was covered by the 50% isodose line as prescription dose.The 60%~70% isodose line covered more than 95% volume of GTV.The fractional dose was 3.0Gy^12.0 Gy,and the total dose was 40.0 Gy^60 Gy in 1~3 weeks.Results All patients were followed for 3 to 16 months after treatment,and the median follow-up duration was 11 months.The complete response and partial response rates were 29.5%（33/112） and 60.7%（68/112） with an overall response rate of 90.2%（101/112）.The 6-month and 12-month local control rates were 98.8%（80/81） and 92.3%（36/39）,and the 6,and 12 month overall survival rates were 100%（81/81） and 94.9 %（37/39）,respectively.The most common side effect was radiation induced pneumonia,which was seen in 9.8%（11/112）.Conclusion LUNATM-260 Gamma Knife could effectively improve the local control and survival rates of NSCLC with low incidence of complications.
出处
《实用癌症杂志》
2011年第6期617-620,共4页
The Practical Journal of Cancer
关键词
非小细胞肺癌
体部立体定向放射治疗
伽玛刀
近期疗效
Non-small cell lung cancer
Stereotactic body radiotherapy
Gamma knife
Short-term therapeutic effectiveness
