摘要
目的：探讨超级伽玛刀立体定向放射治疗对原发性肝癌的近期疗效和不良反应．方法：对肝穿刺活检病理组织学证实的原发性肝癌患者56例（年龄36-82岁）应用立体定向放射系统（SRT）进行治疗，观察其近期疗效和毒副作用．计划治疗3-10枪点，单次剂量3-6Gy，2-5次／wk，照射总量30-50Gy．治疗计划中≥50％的等剂量曲线包饶计划靶区（PTV），平均肝脏剂量均小于25Gy，V30Gy（接受≥30Gy剂量照射的正常肝百分体积）均小于30％．结果：肝癌患者56例（伴有门脉癌栓24例）中，完全缓解（CR）10例（17．9％），部分缓解（PR）30例（53．6％），中位生存时间10．6mo，其中6mo生存率96．4％（54／56），不良反应发生率94．3％，其中消化道反应为92．8％（52／56）．结论：超级伽玛刀技术治疗原发性肝癌能控制肝癌局部和区域性发展，安全、可靠，可提高患者生存率．
AIM： To evaluate the shot-term efficacy and safety of super gamma knife stereotaxic radiation therapy （SRT） for primary hepatic carcinoma （PHC）. METHODS ： Fifty-six PHC patients diagnosed via liver biopsy and histological examination were treated by SRT, and then observed for their short-term effects and side effects. Treatment Planning was 3 to 10 dots, 3 - 6 Gy perfraction, 2 -5 times per week, and the total treatment doses was 30 - 50 Gy. ≥ 50% isodose covered planning target volume （PTV）. Average dose on liver was less than 25 Gy and V30 Gy （ volume percentage of normal liver receiving ≥ 30 Gy dose） was less than 30%. RESULTS： In 56 patients with PHC including 24 patients with cancer emboli in portal vein, the complete remission （CR） rate was 17.9% （10/56）, and the partial remission （PR） rate was 53.6% （30/56）. The mean survival time was 10.6 months, and the 6-month survival rate was 96.4% （54/56）. The side effect rate was 94. 3%, and the digestive tract response rate was 92. 8% （ 52/56 ）. CONCLUSION： Technique of super gamma knife can effectively and safely control the progression of PHC and promote the survival rates of the patients.
出处
《第四军医大学学报》
北大核心
2008年第3期286-288,共3页
Journal of the Fourth Military Medical University
关键词
肝肿瘤
放射疗法
伽玛刀
liver neoplasms
radiotherapy
gamma knife
