摘要
目的评价放弃选择性区域淋巴结照射的三维适形放疗Ⅰ期非小细胞肺癌的毒性和疗效。方法30例经病理组织学和(或)细胞学确诊的Ⅰ期非小细胞肺癌患者接受三维适形放疗,分割剂量3～6Gy/次,5次/周,放疗总量DT63～72Gy。靶区仅包括肿瘤原发灶。结果总有效率为97%。1、2、3年局部控制率分别为73%、60%、53%。1、2、3年生存率分别为72%、56%、52%。随访满5年的12例,5年生存率为35%。未出现3级以上放射性肺炎和放射性食管炎。3例在随访期间出现选择性淋巴结失败。结论三维适形放疗非手术的Ⅰ期非小细胞肺癌安全、有效,近期疗效满意,远期疗效需要进一步观察。放弃选择性区域淋巴结照射并没有明显增加区域淋巴结的复发率。
Objective To evaluate the chnical toxicity and effect of three-dimension confonnal radiation therapy（3DCRT） with elective nodal treatment for stage Ⅰ non-small cell lung cancer（NSCLC）. Methods Thirty patients were diagnosed by pathology or cytology, were treated with 3DCRT. They received a total dose from 63 Gy to 72 Gy, 3-6 Gy/fraction, 5 fractions/week. Only the primary tumor was included in the clinical target volume. Results The efficiency （CR ＋ PR） rate was 97 %. The 1-, 2-, and 3-year local control rate was 73 % （22/30）, 60%（18/30） ,and 53%（ 16/30）, respectively. The overall 1-,2-, and 3-year survival rate was 72% ,56%, and 52%. The overall 5-year survival rate was 35% in 12 patients who were followed 5 years. None of the 30 patients developed grade 3 or severe pulmonary or esophageal toxicity. Only 3 patients （ 10% ） were identified as elective nodal treatment failure. Conclusions 3DCRT is safe and effective for stage I NSCLC patients. The short-term effect is satisfactory. Long-term result needs fitrther follow-up. The recurrence rate is not increased with elective nodal treatment.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2006年第3期188-190,共3页
Chinese Journal of Radiation Oncology
关键词
癌
非小细胞肺/放射疗法
放射疗法
适形
预后
Carcinoma, non-small cell hmg/radiotherapy
Radiotherapy,eonformal
Prognosis
