摘要
目的:研究补康灵对Lewis肺癌小鼠癌性恶病质的改善作用。方法:在小鼠腋后线第6肋间胸膜腔接种Lewis肺癌细胞悬液复制C57BL/6小鼠癌性恶病质模型,观察补康灵对恶病质小鼠的生存状况(体重、摄食量、饮水量、生存期)的影响;检测分析与癌性恶病质相关的血清细胞因子(肿瘤坏死因子-α(TNF-α)、白介素(IL)-1、IL-6)的水平变化。结果:补康灵能显著增加癌性恶病质小鼠摄食量及饮水量,抑制其体重下降(P<0.01或P<0.05),显著降低TNF-α、IL-1、IL-6水平(P<0.05)。结论:补康灵对Lewis肺癌小鼠的癌性恶病质有明显的改善作用,其作用机制可能与其调节TNF-α、IL-1、IL-6等细胞因子有关。
OBJECTIVE：To observe the effect of bukangling on carcinemia in mice with Lewis lung cancer.METHODS：Mice C57BL/6 Lewis lung cancer model were established after mice inoculated with Lewis lung cancer cell suspension through posterior line axillary 6th intercostal extrapleural approach.The changes of physiological conditions（body weight,food and water intake,survival time）,the serum levels of tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6） and interleukin-1（IL-1） were observed in the experiment.RESULTS：Bukangling could significantly increase water and food intake of carcinemia mice,and inhibited the loss of body weight（P0.01 or P0.05）.Levels of TNF-α,IL-1 and IL-6 decreased in Bukangling group obviously（P0.05）.CONCLUSION：Bukangling has remarkably effect on carcinemia in mice with Lewis lung cancer,which may depend on the change of TNF-α,IL-1 and IL-6 levels.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第31期2884-2886,共3页
China Pharmacy
基金
江苏省卫生厅医学科技发展基金资助项目(P200939)
