摘要
从分子遗传学和分子生物学角度述评了载脂蛋白Eε4 (ApoEε4 )等位基因与阿尔茨海默氏病(AD)及相关疾病关系的研究成果。指出ApoEε4是AD的危险因素之一 ,ApoEε4阳性个体比阴性个体患晚发AD的危险性约高 3倍 ,但ApoEε4远不是AD的诊断指标或预测标志。在具有记忆损害的老人中 ,ApoEε4至少可确认为是痴呆的一种因素。ApoEε2可能是区别Lewybody病和晚发AD的遗传因素之一。ApoEε4和脑血管病对血管性痴呆 (VD)可能具有协同作用。
In this review of the studies on molecular genetics and molecular biology of the association of apolipoprotein E(ApoE) ε4 allele with Alzheimer's disease (AD) and cognitive decline, it can be found that ApoEε4 is a risk factor of AD. When ApoEε4 allele is present, the risk of AD is considerably increased, almost 3-fold risk of AD in ApoEε4 positive individuals compared to ApoEε4 negtive individuals. But ApoEε4 is far from being a diagnositic indicator or a predicator of AD. ApoEε4 may at least indicate a predisposion for dementia in memory-impaired individuals. Presence of ApoEε2 allele may be a genetic factor of differentiation between Lewy body disease(LBD) and late onset AD. ApoEε4 and cerebral vascular disease may have a synergistic effect on pathogenesis of vascular dementia (VD).
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
1999年第5期2-5,10,共5页
Journal of Beijing University of Traditional Chinese Medicine
