摘要
目的:探讨中国汉族人载脂蛋白E(ApoE)基因、丁基胆碱酶基因(BCHE)基因多态性与阿尔茨海默病(Alzheimer’sdisease,AD)的相关情况。方法:应用PCR-RFLP方法,在38例患者和40例正常人中观察ApoE和BCHE基因多态性的分布,进行关联分析。结果:AD患者与ApoE基因的等位基因ε4正关联;BCHE基因多态性与AD无关联。结论:在中国人群中,ApoEε4是AD发病的风险因子;CBHE-K等位基因不是AD发病的风险因子。
To detect the correlation between ApoE gene polymorphism, butyrylcholinesterase (BCHE) gene and Alzheimer Disease (AD) in Chinese.Methods:The gene polymorphism of ApoE gene and BCHE gene were genotyped in 38 AD patients and 40 control cases with PCR-RFLP analysis.Results:Ad was associated with ApoE ε4 allele; and there was no association between AD and BCHE gene polymorphism.Conclusions:In Chinese, the ApoEε4 allele is a risk factor of AD, whereas BCHE-K allele is not a risk factor of AD.
出处
《中国现代医学杂志》
CAS
CSCD
2000年第2期5-6,共2页
China Journal of Modern Medicine
