摘要
目的研究原发性癫痫不同发作类型认知功能损害的临床特点。方法采用韦氏成人智力量表(WAIS-RC)分别对原发性癫痫3种发作类型-复杂部分性发作组(甲组)、部分性发作继发全面性发作组(乙组)、全面性癫痫组(丙组),进行全量表智商(FIQ)、言语智商(VIQ)、操作智商(PIQ)及智力因素(A、B、C)、退化指数研究。结果乙组FIQ显著低于丙组(P<0.05)、VIQ显著低于甲组、丙组(P<0.05)、PIQ 3组无显著差异(P>0.05);乙组C因素显著低于甲组、丙组(P<0.05),3组A、B智力因素无显著差异(P>0.05);3组退化指数无组间差异(df=3,F=2.516,P=0.063)。结论原发性癫痫不同发作类型认知功能损害的程度不同:部分性继发全面性发作对全量表智商、言语智商的影响较其他两种发作类型明显,其中对注意/记忆能力(C因素)损害更突出。
Objective To explore the features and severity of cognitive dysfunction in primary epileptic patients with different seizure types.Methods The subjects were grouped by seizure types：Complex partial seizures group（group 1）,Partial seizures evolving to secondarily generalized seizures group（group 2）,and Generalized seizures group（group3）.The Full Intelligence Quotient（FIQ）,Verbal Intelligence Quotient（VIQ）,Performance Intelligence Quotient（PIQ） and sub-test scores were calculated by means of Wechsler Intelligence Scale for Adult-Chinese Revised（WAIS-RC）.Results The FIQ in group 2 was significantly lower than that in group 3（P0.05）.The VIQ in group 2 was significantly lower than that in group 1 and 3（P0.05）.The PIQ showed no difference among the three groups（P0.05）.The C intelligent factor in Group 2 was significantly lower than that in Group 1 and 3（P0.05）.The A and B intelligent factors showed no difference among the 3 groups.The Intelligence degradation index showed no difference among the three groups（df=3,F=2.516,P=0.063）.Conclusion Cognitive dysfunction in epileptic patients with different seizure types varys in severity.Partial seizures evolving to secondarily generalized seizures have significantly more impact on the Verbal Intelligence Quotient than on the other two groups,with the attention / memory（factor C） seriously damaged especially.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2011年第6期513-516,共4页
Journal of Apoplexy and Nervous Diseases
基金
辽宁省教育厅人文社科资助项目
大连市科技局社会发展计划资助项目(D3SF137)
