摘要
目的：研究肺癌组织中ｐ５３、ｐ１６、ｎｍ２３基因蛋白的表达。方法：应用免疫组化ＬＳＡＢ方法检测１２９例肺癌标本中ｐ５３、ｐ１６、ｎｍ２３基因蛋白的表达。结果：ｐ５３、ｐ１６、ｎｍ２３蛋白在肺癌中的阳性表达率分别为５２７％、４５７％、５５８％；３种蛋白阳性表达率与组织学分型无明显相关（Ｐ＞００５）；肺腺癌淋巴结转移阳性组ｐ５３蛋白阳性表达率显著高于淋巴结无转移组（Ｐ＜００５）；ｐ５３蛋白阳性表达组及ｐ１６蛋白阴性表达组的预后差（Ｐ＜００５）；ｎｍ２３蛋白表达与患者预后无关。结论：ｐ５３、ｐ１６蛋白异常表达可做为评估肺癌患者预后的有效指标；未能证实ｎｍ２３基因在肺癌中具转移抑制功能。
Purpose To study the significance of p53p16 and nm23 protein expression in lung cancer. Methods The expression of the three protein was investigated by LSAB immunohistochemical technique in 129 cases of lung cancer. Results The positivity rates of p53p16 and nm23 protein were 527%,457%,558%,respectively, and the expression was not correlated with histological type; there was a positive correlation between p53 expression and lymph node metastasis in adenocarcinoma; the prognosis of the patients with p53 positive and p16 negative tumor was poor; but no correlation between prognosis and nm23 expression was found. Conclusion The change of p53p16 and nm23 gene is correlated with progression of lung cancer; the expression of p53 and p16 has an important effect on predicting the prognosis of lung cancer; nm23 gene has no antimetastastatic function in lung cancer.
出处
《临床与实验病理学杂志》
CAS
CSCD
1999年第3期196-198,I030,共4页
Chinese Journal of Clinical and Experimental Pathology
