摘要
目的观察大鼠全脑缺血再灌流后，CA1区锥体细胞超微结构的变化。方法通过四血管闭塞法全脑缺血模型，采用光、电镜观察了全脑缺血15min再灌流后锥体细胞病理形态学改变及超微结构的变化。结果全脑缺血再灌流48h后CA1区发生了迟发性神经元死亡（DND），锥体细胞超微结构出现了凋亡样改变，同时也观察到部分锥体细胞胞浆出现类似坏死的空泡化现象。结论提示调亡与坏死机制可能共同参与全脑缺血再池流后DND。
Objective To observe the ultrastructural changes of Pyramidal cells of CA1 region in the hippocampus after repefusionfollowing forebrain ischemia. Methods With four-vessel occlusion model of rats, we investigated the pathologic and ultrastructuralchanges by light and electron microscopy after reperfosion following 15 min forebrain ischemia. Results By 48 h after reperfusionfollowing forebrain ischemia, delayed neuronal death (DND) was induced in the CA1 region .The ultrastructure of these pyramidalcells showed apoptosis-like changes. The vacuolar phenomenon of necrosis in cytoplasm of some pyramidal cells was also observed.Conclusion Apoptosis and necrosis may be involved in DND after reperfusion following forebrain ischemia
出处
《第一军医大学学报》
CSCD
1999年第4期289-291,共3页
Journal of First Military Medical University
基金
国家自然科学基金!39570263
广东省自然科学基金!950537
