摘要
目的探讨志贺菌不同群的特征，为临床正确诊断及合理用药提供依据。方法通过志贺菌及沙门菌（SS）大便培养，将志贺菌经生化及血清学进一步鉴定到种、群，并用纸片扩散法测定了13种抗菌药物的敏感性，探讨不同菌群的特征。结果10年分离的福氏志贺菌群和宋内志贺菌群共1554株，分别为1015（65.3％）株、539（34．7％）株，宋内志贺菌逐渐增加：宋内志贺菌感染以14岁以下儿童为主，而福氏志贺菌以31～50岁的中青年为主；二者的临床表现有差别；福氏志贺菌对青霉素类、喹诺酮类、氯霉素、复方磺胺甲嗯唑耐药率高于宋内志贺菌；而对第三代头孢菌素的耐药率明显低于宋内志贺菌。结论福氏志贺菌和宋内志贺菌特征差异多，耐药性不同，临床诊治应区别对待。
Objective To monitor the character of Shigella serogroup to guide the accurate diagnose and rational treatment in clinic. Methods Shigella was cultured with SS culture medium and Shigella species and group was identified with the biochemical and serologic test as well as the susceptibility of Shigella serogroup to antimicrobial agents was tested. Further more, the character of different Skigella serogroups was compared. Results The total 1554 strains including S.flexneri 1015 （65.3%）and S. sonnei 539 （34.7%）respectively isolated from diarrhea patients during ten years. S. sonnei was increasing gradually and becoming the dominant serogroup recently years. Most of S. sonnei infected in less than 14 years old children but S. flexneri happended in youth mainly. Besides, there was different clinical character and resistant rate to antibiotic in different serogroup. The resistant rate to ampicillin, piperacillin quinolones, chloramphenicol and trimethoprim/sulfamethoxazole was higher in S. flexneri than S. sonnei and other than in eephalosporin. Conclusion There are different character and resistance in diffrent serotypes of Shigella so the diagnosis and treatment should according to the serogroup.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2011年第4期307-310,共4页
Chinese Journal of Antibiotics
关键词
志贺菌群
腹泻
特征
耐药性
Shigella serogroup
Diarrhea
Character
Resistance
