摘要
目的:通过研究雌激素对细胞免疫力的调节作用,探讨雌激素的免疫调节功能。方法:用单四唑(MTT)法检测10-8、10-7和10-6mol/L的雌激素在体外对刀豆蛋白A(ConA)刺激的胸腺细胞增殖能力。结果:三种浓度的雌激素组与对照组相比,胸腺细胞的增殖能力均受到抑制,其抑制效应有剂量和时间依赖性。结论:雌激素对细胞免疫力有抑制作用。
Objective: The effects of estrogen on cellular immunity were investigated to explore the immunomodulatory properties of estrogen. Methods: In the present study, the in vitro influences of estrogen at 10^(-8),10^(-7 )and 10^(-6) mol/L on the ConA-induced proliferation of thymocytes were determined by MTT assay. Results: The results showed that estrogen at all concentrations we used suppressed the ConA-induced proliferation of thymocytes. The inhibitive effects had dose- and time- dependent pattern. Conclusion: These results suggested that estrogen had inhibiting effects on the cellular immunity.
出处
《医学研究生学报》
CAS
2005年第7期588-590,共3页
Journal of Medical Postgraduates
关键词
雌激素
胸腺细胞
增殖
细胞免疫
Estrogen
Thymocyte
Proliferation
Cellular immunity
