摘要
目的比较血管加压素与肾上腺素对大鼠脑复苏效果的研究。方法60只雄性SD大鼠建立心搏骤停模型，随机（随机数字法）分为4组（n=15／组）：假手术组（sham operated group，shamgro）、阴性对照组（neg-gro）、血管加压素组（vas-gro）、肾上腺素组（adr-gro）。分别记录血压变化，并取大鼠脑组织标本。结果在复苏30min后vas-gro与adr-gro复苏成功率差异无统计学意义（P〉0．05）；在自主循环恢复的30min内（1，2，5，10，20，30min）vas-gro的平均动脉压均高于adr-gro；测得MDA，SOD，GSH的量vas-gm，sham-gro，adr-gro互相之间差异有统计学意义（P〈0．05）。结论血管加压素与肾上腺素在大鼠心肺复苏过程中成功率相近，但血管加压素能维持复苏后平均动脉压在较高水平，继而会更好的增加脑灌注，减轻脑细胞损伤。
Objective To compare the effects of vasopressin and adrenaline on cerebral resuscitation in rats. Method Sixty male SD rats were used to set the animal model of cardiac alTest and were randomly （random number） divided into 4 groups （n = 15/group） ： sham operation group （sham-gro）, negative control group （neg-gro）, vasopressin group （vas-gro） and adrenaline group （adr-gro）. Blood pressure was recorded, and brain tissue samples were obtained. Results There was no significant difference in the recovery rate between vas-gro and adr-gro 30 min after resuscitation （P 〈 0.05）. The mean blood pressure in vasgro was higher than that in adr-gro within 30 rain （ 1,2, 5, 10, 20, 30 min） after restoration of spontaneous circulation. The measured MDA, SOD and GSH were significantly different （ P 〈 0.05 ） between each two groups among vas-gro, sham-gro and adr-gro. Conclusions The recovery rate was similar between vasopressin group and adrenaline group during cardiopulmonary resuscitation in rats. However, vasopressin can to maintain the mean arterial pressure at a higher level after resuscitation, which can the increase the cerebral perfusion and reduce brain cell damage.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2011年第3期277-280,共4页
Chinese Journal of Emergency Medicine
关键词
心肺复苏
血管加压素
肾上腺素
大鼠
脑复苏
Cardiopulmonary Resuscitation
Vasopressin
Adrenaline
Rat
Cerebral Resuscitation
