摘要
目的研发由电磁阀系统总控制、压缩气体驱动的新型大鼠电刺激诱发心跳骤停和复苏的机械装置,并探讨其有效性和安全性。方法选用Sprague-Dawley雄性大鼠20只,应用自主开发研制的心跳骤停和复苏机械装置,持续交流电经右心室内膜致颤。在6min心室颤动后,开始给予6min的机械胸外按压和同步机械通气,随后双向波经胸体外除颤。结果15只大鼠复苏成功,自主循环恢复率为75%。电刺激后所有大鼠立刻出现心室颤动,3min的电刺激停止后动物持续表现为室颤而没有自发转复心律现象。心肺复苏期间恢复自主循环组其冠状动脉灌注压恒定在24mmHg左右,显著高于未能恢复自主循环组。结论本新型大鼠心跳骤停和心肺复苏装置的有效性和安全性高,可最大限度减少实验的误差,具有一定的推广应用前景。
Objective To explore a novel mechanical device innovated by ourselves for the resuscitation of cardiac arrest in rat. Method Ventricular fibrillation （VF） was induced and maintained by an alternating electric current delivered to the right ventricular endocardium in 20 Sprague-Dawley rats. CPR, including mechanical ventilation and precordial compression with a pneumatic piston device was initiated after 6 min of untreated VF. Defibrillation was attempted after 6 min of CPR. Results Fifteen animals were successfully rescued. The rate of restoration of spontaneous circulation （ROSC） was 75 % . VF immediately occurred after electrical stimulation. No spontaneous cardiovertion was observed during VF period. In animals with ROSC, the coronary perfusion pressure was maintained at 24 mmHg, which was significantly greater than those without ROSC. Conclusions This new device for CPR in rat is characterized by high efficacy and safety, which can minimize the experimental deviation. Therefore it provides a good tool for the basic research of CPR.
出处
《中华急诊医学杂志》
CAS
CSCD
2007年第4期387-389,共3页
Chinese Journal of Emergency Medicine
基金
广东省自然科学基金（5001791）
专利号：200620063261.9,200610037154.3.
关键词
心跳骤停
心肺复苏
机械装置
Cardiac arrest
Cardiopulmonary resuscitation
Mechanical equipment
