期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微小RNA在肿瘤转移中的调节作用 被引量：2

Regulatory role of microRNA in the metastasis of tumor
暂未订购
导出
摘要 微小RNAs(miRNA)是近年来肿瘤学领域研究的热点,通过抑制靶mRNA翻译或诱导靶mRNA降解在转录后水平调控基因表达,具有癌基因或抑癌基因的功能。近年来有研究发现微小RNAs与肿瘤转移密切相关,本文就与miRNAs在肿瘤转移中的调节作用进行综述。 MicroRNAs（miRNA） is the hotpoint of oncology research recently.MiRNAs regulate target genes by inhibiting mRNA translation or inducing mRNA degradation at the post-transcriptional level.Recent evidences have shown that some miRNAs can act as oncogenes or tumor suppressors.It have been demonstrated that aberrant expression of miRNAs is closely associated with metastasis of various cancers.Here we discussed the role of miRNAs in regulating the metastasis of tumor.
作者 王映霞 吴宜林
机构地区 中南大学湘雅二医院妇产科
出处 《国际病理科学与临床杂志》 CAS 2010年第6期501-506,共6页 Journal of International Pathology and Clinical Medicine
关键词 微小RNA 肿瘤 转移 microRNA cancer metastasis
分类号 R73-3 [医药卫生—肿瘤]
  • 相关文献

参考文献2

二级参考文献78

  • 1Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA 2005; 11:1753-1761.
  • 2Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science 2005; 309:1519-1524.
  • 3Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116:281-297.
  • 4Fitzgerald K. RNAi versus small molecules: different mechanisms and specificities can lead to different outcomes. Curr Opin Drug Discov Dev 2005, 8:557-566.
  • 5Brennecke J, Stark A, Russell R.B, Cohen SM. Principles of microRNA-target recognition. PLoS Biol.2005; 3:e85.
  • 6Croce CM, Calin GA. miRNAs, cancer, and stem cell division. Cell 2005; 122:6-7.
  • 7Chen CZ, Li L, Lodish HF, Bartel DE MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303:83- 86.
  • 8Hwang HW, Mendell JT. MicroRNAs in cell proliferation, cell death, and tumorigenesis. Br J Cancer 2006; 94:776-780.
  • 9Hammond SM. MicroRNAs as oncogenes. Curr Opin Genet Dev 2006; 16:4-9.
  • 10Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006; 6:259-269.

共引文献218

同被引文献50

  • 1Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993,75(5):843-854.
  • 2Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let- 7 RNA regulates developmental timing in Caenorhabditis elegans[J]. Nature, 2000,403(6772):901-906.
  • 3Chen CZ. MicroRNAs as oncogenes and tumor suppressors [J]. N EnglJ Med, 2005,353(17): 1768-1771.
  • 4Bhaumik D Scott GK, Schokrpur S, et al. Expression of microRNA-146 suppresses NF-kappa B activity with reduction of metastatic potential in breast cancer ceils [J]. Oncogene, 2008,27(42):5643-5647.
  • 5Tavazoie SF, Alarcon C, Oskarsson T, et al. Endogenous human microRNAs that suppress breast cancer metastasis [J]. Nature, 2008,451(7175) : 147-152.
  • 6Scott GK, Goga A, Bhaumik D, et al. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR- 125a or miR-125b [J].J Biol Chem, 2007,282(2):1479-1486.
  • 7Gregory PA, Bert AG, Paterson EL, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 [J]. Nat Cell Biol, 2008,10(5):593- 601.
  • 8de Krijger I, Mekenkamp LJ, Punt cJ, et al. MicroRNAs in colorectal cancer metastasis [J]. J Pathol, 2011,224(4):438- 447.
  • 9Fu X, Han Y, Wu Y, et al. Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis [J]. Eur J Clin Invest, 2011,41 (11): 1245-1253.
  • 10Johnson SM, Grosshans H, Shingara J, et al. R.AS is regulated by the let-7 microRNA family [J]. Cell, 200$,120(S):63S-647.

引证文献2

二级引证文献13

国际病理科学与临床杂志
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部