摘要
目的：探讨急进高原低氧环境，正常适应人群血浆肾素（ＰＲＡ） 、血管紧张素ＩＩ（ＡＴ－ Ⅱ）、醛固酮（ＡＬＤ） 、心钠素（ＡＮＰ） 的变化及其在高原适应中的生理意义。方法：以急进高原的健康人群为对象，年龄１８～２１ 岁，均为男性。采用放射免疫法测定血浆ＰＲＡ、ＡＴＩＩ、ＡＬＤ、ＡＮＰ浓度。结果：进驻高原后血浆ＰＲＡ、ＡＬＤ、ＡＮＰ浓度显著低于进驻高原前（统计结果分别为：ｔ＝ ３ ．０３０４，Ｐ＜ ０ ．０１ ；ｔ＝ ４ ．１５７９ ，Ｐ＜０．０１ ；ｔ＝２ ．２３９３，Ｐ＜０ ．０５）；进驻高原后血浆ＡＴ－ Ⅱ浓度显著高于进驻高原前（ｔ＝ ２．４４９６，Ｐ＜０ ．０５） 。结论：人对低氧应急的早期适应过程中，血浆血管活性物质会发生一系列的代偿性改变，但血管活性物质的多维立体调节网络有待进一步研究。
Objective:To Investigate the changes of vasoactive material in early stage of adaptaion in human being entering high altitude environment rapidly. Methods:The subjects were divided into the group before entering high altitude and group after entering high altitude, the vasoactive material renin activity (PRA),angiotensin II(AT-Ⅱ),aldosterone (ALD)and atrial natriuretic peptide (ANP) in human plasma were detemined with radioimmunoassay.Results:The plasma PRA, ALD and ANP in group after entering high altitude were reduced significantly than those in the group before entering high altitude (t=3.0304,P<0.01;t=4.1579,P<0.01;t=2.2393,P<0.05); the AT-Ⅱ in group after enteing high altitude was markedly increased than that of the group before entering high altitude (t=2.4496,P<0.05) Conclusion:The results showed the compensatory changes of plasma PRA, AT-Ⅱ, ALD, ANP during the early adaptation stage in human being entering hypoxia environment rapidly.
出处
《解放军预防医学杂志》
CAS
北大核心
1999年第6期406-408,共3页
Journal of Preventive Medicine of Chinese People's Liberation Army
基金
武警医学院科研基金!资助项目(WY97- 3)
关键词
高原
低氧
适应
血管活性物质
high altitude hypoxia, adaptation, vasoactive material
