摘要
目的比较奥氮平与氯氮平维持治疗精神分裂症患者1年的有效性和不良反应。方法对符合CC-MD-3精神分裂症诊断标准的患者,分别使用奥氮平和氯氮平治疗,病程≤5年稳定期的138例精神分裂症患者给予1年的维持治疗,以治疗中断率、中断前治疗时间并结合临床疗效评价抗精神病药的总体有效性,采用不良事件和实验室检查评价安全性,并评估患者出现的不良反应。结果随访1年,138例患者中有60例(43.5%)中断治疗。两药组间治疗中断率及中断前治疗时间的差异均无统计学意义(P>0.05);56例(40.6%)完成1年随访并达到临床痊愈标准,临床痊愈率在两组间的差异无统计学意义(P>0.05)。两药总的不良反应发生率的差异无统计学意义(P>0.05),但镇静作用、锥体外系不良反应、月经紊乱及体质量增加等不良反应在不同药物间的差异有统计学意义(P<0.01和0.05)。结论两药治疗精神分裂症患者1年的临床疗效相当,但药物的不良反应各异。
Objective To compare the effectiveness and side effects of olanzapine and clozapine and to schizophrenia after 1 year maintenance treatment.Methods A total of 138 patients suffering from schizophrenia for less than 5 years who took clozapine or olanzapine maintenance treatment were recruited,and followed up to 1 year.The rates of treatment discontinuation and time to discontinuation combined with clinical efficacy evaluation were as the outcome measurement.The self-reported adverse events and lab tests were administered to evaluate side effects.Results At the end of the study,43.5% patients discontinued their treatment;and 40.6% patients completed the 1 year follow-up and attained clinical remission.There were no significant differences in the rate of discontinuation and time to discontinuation among the two groups.There was no significant difference in the total rate of side effects among the two groups,with significantly different profiles in sedation,extrapyramidal symptoms,weight gain and menstrual irregularities.Conclusion The results indicate the clinical effectiveness of 1 year maintenance treatment of the two drugs are similar,with some difference in side effect profiles.
出处
《四川精神卫生》
2010年第4期203-205,共3页
Sichuan Mental Health
