摘要
目的探讨血清白细胞介素-1β(IL-1β)、白细胞介素-17(IL-17)水平与首发精神分裂症患者治疗效果的关系。方法选取2017年1月~2019年1月杭州市第七人民医院收治的200例首发精神分裂症患者作为研究组,入院当天给予患者奥氮平,治疗时间为4周,选取60名同期健康体检者作为对照组。记录治疗前及治疗4周后患者阳性和阴性症状量表(PANSS)得分,采用酶联免疫法测定两组人群血清IL-1β、IL-17水平。根据治疗有效率将研究组分为A组(痊愈,30例)、B组(显著进步,60例)、C组(好转,72例)和D组(无效,38例),比较各组治疗前后血清IL-1β、IL-17水平。采用Pearson相关性分析患者血清IL-1β、IL-17水平与PANSS评分的相关性。结果研究组血清IL-1β、IL-17水平高于对照组,差异有统计学意义(P<0.05)。研究组治疗后血清IL-1β、IL-17水平低于治疗前,差异有统计学意义(P<0.05)。与本组治疗前比较,A、B和C组血清IL-1β水平显著降低,A、B组血清IL-17水平显著降低,差异有统计学意义(P<0.05)。进一步两两比较,四组患者血清IL-1β水平差异均有统计学意义(P<0.05),且A组水平最低。此外,A组血清IL-17水平显著低于其他三组,B组血清IL-17水平显著低于D组,差异有统计学意义(P<0.05)。血清IL-1β、IL-17水平与PANSS评分呈正相关(r=0.386、0.544,P<0.05)。结论IL-1β与IL-17与精神分裂症患者发病具有密切关系,可一定程度反映治疗效果,对评估患者临床效果具有重要价值。
Objective To explore the relationship between serum interleukin-1β(IL-1β),interleukin-17(IL-17)levels and the therapeutic effect in patients with first-episode schizophrenia.Methods A total of 200 patients with first-episode schizophrenia admitted in Hangzhou Seventh People′s Hospital from January 2017 to January 2019 were se-lected as the research group.Olanzapine was given to the patients on the day of admission and the treatment time was 4 weeks.At the same time,sixty healthy people were selected as the control group.The positive and negative symptoms scale(PANSS)scores were recorded before and 4 weeks after treatment.The serum IL-1βand IL-17 levels of two groups were measured by enzyme-linked immunosorbent assay.According to the effective rate of treatment,the research group was divided into group A(recovery,30 cases),group B(significant progress,60 cases),group C(improvement,72 cases)and group D(ineffective,38 cases).The serum IL-1βand IL-17 levels were compared before and after treatment in each group.Pearson correlation was used to analyze the correlation between serum IL-1β,IL-17 levels and PANSS score in patients.Results The levels of serum IL-1βand IL-17 in the research group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum IL-1βand IL-17 in the research group after treatment were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).Compared with before treatment in the same group,the serum levels of IL-1βin groups A,B and C were significantly reduced,and the serum levels of IL-17 in groups A and B were significantly reduced,the dif-ferences were statistically significant(P<0.05).Further pairwise comparison,the differences in serum IL-1βlevels of the four groups were statistically significant(P<0.05),and the level in group A was the lowest.In addition,the serum IL-17 levels in group A were significantly lower than those in the other three groups,and the serum IL-17 levels in group B were significantly lower than those in group D,and the differences were statistically significant(P<0.05).The levels of serum IL-1βand IL-17 were posi-tively correlated with PANSS score(r=0.386,0.544,P<0.05).Conclusion IL-1βand IL-17 are closely related to the onset of schizophrenia,which can reflect the therapeutic effect to a certain extent,and have an important value in evaluating clinical effect of patients.
作者
严辞
汪彦博
YAN Ci;WANG Yanbo(Department of Psychiatry,Hangzhou Seventh People′s Hospital,Zhejiang Province,Hangzhou 310000,China;the Third Affiliated Hospital of Zhejiang Chinese Medical University,Zhejiang Province,Hangzhou 310000,China)
出处
《中国医药导报》
CAS
2019年第36期178-180,F0003,共4页
China Medical Herald
基金
浙江省医药卫生科技计划项目（2017WY544）
