摘要
目的：探讨复方乙酰水杨酸片中非那西丁和咖啡因的含量测定方法。方法：在乙醇中溶解样品，用０２ｍｏｌ／ＬＮａＯＨ水解乙酰水杨酸后，以ｐＨ６５磷酸盐缓冲液为溶剂进行定量，采用多元回归分光光度法。结果：非那西丁和咖啡因的平均回收率分别为９９８％和９９９％，ＲＳＤ为０７２％和０５２％。结论：样品的测定结果同部颁标准法比较在准确度上无显著差异。
OBJECTIVE: To determine phenacetin and caffeine in compound acetylsalicylic acid tablets. METHODS: Multiple regression spectrophotometry was adopted as follow:The sample is dissolved in ethanol,add solution of 02mol/L NaOH to hydrolysis acetylsalicylic acid,the components are determined in phosphate salt buffet (pH 6.5). RESULTS: The average recoveries for phenacetin and caffeine were 99.8% and 99.9%,with RSD 0.72% and 0.52%,respectively. CONCLUSION: Accuracy of the method was compared with official quantitative analysis and no significant difference was found.
出处
《药学实践杂志》
CAS
1999年第1期31-33,共3页
Journal of Pharmaceutical Practice
关键词
乙酰水扬酸
非那西丁
咖啡因
分光光度法
multiple regression spectrophotometry
compound acetylsalicylic acid tablets
phenacetin
caffeine
determination
