摘要
本文研究了复方阿斯匹林片中阿斯匹林、非那西丁和咖啡因含量同时测定的紫外分光光度法的最佳实验条件,并简述偏最小二乘法(PLS)在多组分同时测定中的基本原理和应用。三组分模拟试样回收率平均值的置信区间分别为100.1±0.23%,100.0±0.25%和100.1±0.33%(置信度95%)。PLS法是一种理想的多组分测定方法,计算速度较快,结果更准确可靠,尤其适用于成批试样的分析,为微机控制的紫外可见分光光度计提供了一种新方法。
The optimum experimental condition for simultaneous UVspectrophotometric determination of the contents of aspirin, phenacetin and caffeine in aspirin compound tablets (APC) and the basic principle and application of partial least squares method(PLS) in simultaneous multicomponent determination have been studied. Confidence intervals of the three components are 100.1±0.23%(aspirin), 100.0±0.25% (phenacetin) and 100.1±0.33% (caffeine) (confidence 95%). No information has ever been available in the literature for the application of PLS in pharmaceutical analysis. Compared with other traditional computing methods, PLS is a more perfect multicomponent determination method. It is especially applicable to analyzing samples in batches. It is faster and produces more accurate and reliable results. PLS provides a new method for in-line UV-visible spectrophotometric automation.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第9期684-689,共6页
Acta Pharmaceutica Sinica
关键词
分光光度法
阿斯匹林
组分
Partial least squares method (PLS)
UV-spectrophotometry
Aspirin compound tablets (APC)
Aspirin
Phenacetin
Caffeine
