摘要
目的：成功地建立金黄地鼠舌癌模型。方法：采用０．５％ＤＭＢＡ丙酮液涂布右舌侧缘局部机械刺激。结果：１８周后成功地建立了金黄地鼠舌癌模型。在舌癌诱发过程中，舌粘膜经历了癌前病变和成癌两个时期。在癌前病变中又分为炎症、变性、再生和单纯上皮增生四个阶段，而癌变阶段则表现为上皮异常增生、原位癌和浸润性鳞癌三个阶段，该模型的组织学改变和人舌粘膜白斑及鳞癌基本一致。结论：该模型具有较稳定、重复性好、易建立、成癌率高等优点，和人舌癌的形成极其相似，为舌癌的病因学、生物学及治疗学研究，提供了良好的动物模型。
Objective: To establish hamster lingual carcinoma model succesfully. Methods: Local application of 0.5%DMBA acetone solution and chronic mechanical irritation on right side of hamster tongue. Results: Hamster lingual carcinoma model was established succesfully after 18 weeks. It went through two phases:precancer and cancer phase. In precancer phase, it could be devided into four periods: inflammationt, denaturation, regeneration and pure epthelial hyperplasia. In cancer phase, it went through three periods: abnormal epthelial hyperplasia, in situ cancer and invasive cancer. The histological change of this model was consistent with that of human tongue leukoplakion and squamous cell carcinoma. Conclusions: The hamster lingual carinoma model was more stable, easier to establish and duplicate, with high ratio of tumor-growing. It resemble the formation of human tongue cancer. It provided good animal carcinoma model for the study of pathogenesis biology and therapeutics of tongue cancer.
出处
《口腔颌面外科杂志》
CAS
1999年第2期106-108,共3页
Journal of Oral and Maxillofacial Surgery
关键词
舌癌
模型
组织学
HamsterLingual carcinoma modelHistology
