摘要
目的归纳总结舌癌的造模方法以及成模条件,为探索更接近于中西医结合病证的舌癌动物模型奠定基础,进而推动现代临床对舌癌的研究与诊治进程。方法通过分析中国知网、万方、Web of Science以及PubMed数据库中舌癌动物模型的造模方法和模型特点,评价其与中医证候和西医临床病症特点的吻合度。结果总结发现,舌癌动物模型的造模方法有3种,分为化学致癌剂诱发模型、移植性肿瘤动物模型以及遗传工程动物模型。其中,移植性肿瘤动物模型的临床吻合度最高,其次为遗传工程动物模型,化学致癌剂诱发模型的临床吻合度最低。结论构建符合中医证候和西医病症特点的舌癌动物模型,是今后开展舌癌研究治疗的必要途径。
Objective To lay the foundation for exploring the animal model of tongue cancer that is closer to the disease of integrated Chinese and Western medicine,and summarize the modeling methods and conditions of tongue cancer,so as to promote the modern clinical research,diagnosis and treatment of tongue cancer.Methods By analyzing the modeling methods and characteristics of tongue cancer animal models in CNKI,Wanfang,Web of Science and PubMed databases,the consistency of the models with TCM syndromes and Western clinical syndromes was evaluated.Results It is concluded that there are three methods to model the animal model of tongue cancer,including chemical carcinogenic agent induced model,transplanted tumor model and genetically engineered animal model.The clinical anastomosis of transplanted tumor animal model was the highest,followed by genetic engineering animal model,and the clinical anastomosis of chemical carcinogenic agent induced model was the lowest.Conclusion To construct the animal model of tongue cancer which accords with the characteristics of TCM and Western medicine is the necessary way to carry out the research and treatment of tongue cancer in the future.
作者
刘莹
安一珂
赵日开
杨卉妍
苗明三
LIU Ying;AN Yike;ZHAO Rikai;YANG Huiyan;MIAO Mingsan(College of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《世界科学技术-中医药现代化》
北大核心
2025年第5期1471-1476,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
河南省重大专项(221100310400):道地宛药全产业链关键技术研究及应用,负责人:许二平
河南省国际合作重点项目(231111521200):豫药外用防治免疫性疾病的现代研究,负责人:白明
岐黄学者(国中医药人教函2022-6),负责人:苗明三。
关键词
舌癌
舌岩
动物模型
中西医
临床吻合度
Tongue cancer
Lingual rock
Animal model
Chinese and western medicine
Clinical anastomosis
