摘要
目的探讨新疆哈萨克族原发性高血压患者中高尿酸血症的患病率及其影响因素。方法应用四阶段分层整群随机抽样方法入选新疆7个区35岁以上原发性高血压哈萨克族患者1909例,进行问卷、体检、生化指标测定等检查。采用logistic回归分析该人群的高尿酸血症主要影响因素。结果原发性高血压患者高尿酸血症的患病率为4.6%,男性为6.7%,女性为2.2%,男性高于女性(P<0.01);35～45、>45～55、>55～65、>65～75、>75岁各年龄组的原发性高血压患者高尿酸血症患病率分别为4.70%、4.69%、4.60%、3.91%、4.68%。多因素logistic回归分析得到高三酰甘油(OR=1.77,95%CI1.11～2.85)、高胆固醇血症(OR=2.58,95%CI1.62～4.10)、高尿素氮(OR=1.28,95%CI1.11～1.47)、肥胖(OR=1.53,95%CI0.67～3.50)、经常饮酒(OR=2.12,95%CI1.21～3.69)为危险因素。女性(OR=0.38,95%CI0.22～0.68)为保护因素。结论新疆哈萨克族原发性高血压患者高尿酸血症患病率相对较低,性别、高三酰甘油、高胆固醇血症、高尿素氮、肥胖、饮酒等均可影响高尿酸血症患病率,不同性别的影响因素不同。
Objective To investigate the prevalence of hyperuricemia and its associated risk factors in treated and untreated essential hypertensive patients in Xinjiang Kazak area.Methods This cross-section study was performed in 1909 essential hypertensive patients aged 35 years old or over in Xinjiang Kazaks by using a four-stage selected random sampling method.All patients underwent an investigation composed of a standardized questionnaire,physieal and biochemical examination.Risk factors were analyzed by logistic regression model.Results The prevalence of hyperuricemia in hypertensives in Kazaks for the general population was 4.6%,6.7% or 2.2% for the males and females respectively.The males had higher rate than females （P0.01）.The prevalence was 4.70%,4.69%,4.60%,3.91% and 4.68% for 35-45,45-55,55-65,65-75,75 and over years old respectively.Multivariate stepwise logistic regression analyzing the significant risk factors showed high triglycerides （OR=1.77,95% CI 1.11-2.85）,high total cholesterol （OR=2.58,95% CI 1.62-4.10）,high urea nitrogen （OR=1.28,95% CI 1.11-1.47）,obesity （OR=1.53,95% CI 0.67-3.50）,alcohol drinking （OR=2.12,95% CI 1.21-3.69）.Female （OR=0.38,95% CI 0.22-0.68） was the protective factor.Conclusion Essential hyperuricemia is relatively less common in Xinjiang Kazak area hypertensive patients.The associated risk factors of hyperuricemia include alcohol consumption,elevated serum uric acids,high triglycerides,high total cholesterol,high urea nitrogen,obesity.The effect of these factors is different between genders.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2010年第9期832-836,共5页
Chinese Journal of Hypertension
基金
新疆维吾尔自治区重大科技专项课题(200733146-3)
