期刊文献+

老年高血压病患者颈动脉粥样硬化程度与血清尿酸和胆红素水平的关系 被引量:4

Clinical study on the association of serum uric acid and serum bilirubin with carotid atherosclerosis in aged patients with hypertension
暂未订购
导出
摘要 目的 :观察血清尿酸和胆红素水平变化与颈动脉粥样硬化程度的关系。方法 :选择老年高血压病患者92例 ,按颈动脉超声检测结果分内膜增厚组、斑块形成组、管腔狭窄组 ,测定三组患者的血清尿酸和胆红素水平 ,并进行统计学分析。结果 :颈动脉粥样硬化程度越严重 ,血清尿酸水平越高 ,三组间比较差异有显著性 (P<0.05) ,血清总胆红素和间接胆红素水平越低 ,三组间比较差异显著 (P<0.01) ,直接胆红素差异不显著 (P>0.05)。结论 :老年高血压病患者的血清尿酸和 (或 )胆红素水平变化与动脉粥样硬化关系密切。 Objective:To explore the association of serum uric acid and serum bilirubin with carotid atherosclerosis in aged patients with hypertension.Methods:92 aged patients with hypertension whose CCAs were detected by ultrasound were divided into increased IMT group,atheroma group and narrow luminal diameter group. Their serum uric acid and serum bilirubin levels were measured and compared.Results:Those with higher serum uric acid and lower serum total bilirubin and serum indirect bilirubin showed more severe carotid atherosclerosis. There was significant statistical difference between three groups (P<0.05). Serum direct bilirubin showed no statistical difference(P>0.05).Conclusion:Serum uric acid and/or serum bilirubin might be closely related to in atherosclerosis in aged patients with hypertension.
出处 《现代医药卫生》 2004年第14期1322-1323,共2页 Journal of Modern Medicine & Health
关键词 高血压 颈动脉粥样硬化 血清 尿酸 胆红素 老年人 Carotid atherosclerosis Serum uric acid Serum bilirubin Hypertension Senility
  • 相关文献

参考文献7

  • 1[1]Levine W, Dyer AR, Shekelle RB, et al. Serum uric acid and 11.5 year mortality of middle - aged women: findings of the Chicago Heart Association Detection Project in Industry [ J ]. J Clin Epidemiol, 1989,42: 257.
  • 2[2]Waddington C. Elevated uric acid can raise risk for CHD [J]. Cardiol Today, 1999,2:15.
  • 3[3]Beevers DG, Lip GY. Is uric acid really an independent cardiovascular risk factor? [J ]. Lancet, 1998,352:1556.
  • 4[4]Franse LV, Pahor M, Di Bari M, et al. Serum uric acid, diuretic treatment and risk of cardiovascular events in the Systolic Hypertension in the Elderly Program(SHEP) [J] .J Hypertens, 2000,18:1149.
  • 5党爱民,刘国仗.尿酸与心血管事件[J].中华心血管病杂志,2003,31(6):478-480. 被引量:244
  • 6孙全格,童文玲,武文,郑强荪,柳荫,薛玉生.血清总胆红素与冠状动脉狭窄的相关性[J].心脏杂志,2003,15(5):432-433. 被引量:11
  • 7[7]Schwertner HA. Association of smoking and low serum bilirubin antioxidant concentrations [J]. J Atherosclerosis, 1998, 136: 383.

二级参考文献37

  • 1Gertler MM, Garn SM, Levine SA. Serum Uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med, 1951,34 : 1421-1431.
  • 2Beard Jt. Serum uric acid and coronary heart disease. Am Heart J,1983,106:397-400.
  • 3Alderman MH, Cohen H, Madhavan S, et al. Serum uric acid and cardiovascular events in successfully treated hypertensive patients.Hypertension, 1999,34 : 144-150.
  • 4Bickel C, Rupprecht HI, Blankenberg S, et al. Serum uric acid as an independent predictor of mortality in patients with angiographical]y proven coronary artery disease. Am J Cardiol, 2002,89:12-17.
  • 5Brand FN, McGee DL, Kannel WB, et al. Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. Am J Epidemiol, 1985,121 : 11 -18.
  • 6Bonora E, Targher G, Zenete MB, et al. Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atheroaclerosis Risk Factors Study. Int J Obes Relat Metab Disord,1996,20:975-980.
  • 7Rathmann W, Funkhouser E, Dyer R, et al. Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study.Coronary Artery Risk Development in Young Adults. Ann Epidemiol, 1998,8:250-261.
  • 8Ward HI. Uric acid as an independent risk factor in the treatment of hypertension.Lancet, 1998,352:670-671.
  • 9DeScheeder IK, van de Kraay AM, Lamers JM, et al. Myocardial malodialdehyde and uric acid release after short-lasting coronaryy occlusions during angioplasty: potential mechanisms for free radical generation. Am J Cardiol, 1991,68:392-395.
  • 10Ginsberg MH, Kozin F, O'Malley M. et al. Release of platelet constituents by monosodium urate crystals. J Clin Invest, 1997,60:999-1007.

共引文献253

同被引文献26

引证文献4

二级引证文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部