摘要
应用3种肿瘤细胞模型对未破壁灵芝孢子、机械破壁灵芝孢子和全灵芝剥壁孢子进行抗肿瘤试验研究。结果表明,未破壁及不同破壁方式的灵芝孢子对人恶性乳腺癌细胞(MT-1)、人恶性淋巴癌细胞株(Jurkat)、人恶性脑肿瘤细胞(U343)均有不同程度的抑制作用,抑制效果强弱为全灵芝剥壁孢子>机械破壁灵芝孢子>未破壁灵芝孢子,表明破壁的确能提高灵芝孢子对肿瘤细胞的抑制作用,而且选择破壁的方法也很重要,生物酶法破壁能使灵芝孢子的生物活性成分得到充分释放,所以大大提高灵芝孢子的功效。
The objective of this paper was to compare the inhibitory effects in intact Ganoderma spores with sporoderm-broken spores which were broken by enzymatic method and physical method on three kind of tumour cells including MT-1 （Human Breast Cancer）, Jurkat （Human T cell lymphoblast-like cell line） and U343 （Human astrocytoma cell line）. The experiments indicated that the inhibitory effects of Ganoderma spores on cancer cell growth were sporoderm-broken spores （broken by en- zymatic method） 〉 sporoderm-broken spores （broken by physical method） 〉 intact spores. The sporoderm-broken spores broken by enzymatic method improved the inhibitory effects significantly.
出处
《中国食用菌》
北大核心
2010年第5期33-36,共4页
Edible Fungi of China
基金
广东省科技型中小企业技术创新基金项目(ZX032280)
广东省中国科学院全面战略合作项目(2009B091300139)
关键词
灵芝孢子
破壁
肿瘤细胞
Ganoderma spores
Sporoderm-broken
Tumour cells
