摘要
本文以抑制硫代巴比妥酸反应物的生成为指标,测定了十四种化合物的抗氧化活性,并估测了其中十一种化合物与-OH反应的动力学常数,发现它们的量效关系为:1.抗氧化活性与浓度成直线相关性,按其抗氧化活性由大到小排列顺序如下:N、N-二乙基硫代氨甲酸钠;4-羟基桂皮酸二乙胺基乙基醋盐酸盐;1-色氨酸;S,2(3-氨基丙基氨基)乙基硫代磷酸;S,2-氨基乙基异硫脲盐酸盐:dl-蛋氨酸;dl-组氨酸;乙醇:烟酰胺;柠檬酸钠;甘氨酸.2.抗坏血酸与1-半胱氨酸低浓度时促氧化,高浓度时抗氧化.3.还原性谷胱甘肽其抗氧化活性与浓度的关系成指数型.
The antioxidative activity of fourteen kinds of compounds was studied,using the inhibition rate of TBAS formation as an indicator, and three different relationships between antioxidative activity and concentration were found.(1) Linear relation was found in 11 kinds of compounds, which are listed below from higher antioxidative activity to lower: sodium diethyldithiocarbomate; diethylaminoethyl-p-hydroxy-cinnamate hydrochloride; 1-tryptophan; S, 2- (3-aminopropyl-amino)-ethyl phosphorothioic acid; S, 2-aminoethylisothiourea hydrochloride; dl-methi-onine;dl-histindine; ethyl alcohol; sodium citrate; glycine. (2) Ascorbate and 1-cystine at low concentration promoted the formation of TBAS, but inhibited it at high concentration. (3) Reduced glutathione showed antioxidative activity, and the relation between the effect and its concentration was exponential.
出处
《生物物理学报》
CAS
CSCD
北大核心
1990年第3期383-387,共5页
Acta Biophysica Sinica
