摘要
目的:探讨组织多普勒Tei指数(TDI-Tei指数)及N端脑钠肽前体(NT-proBNP)评价急性冠脉综合征(ACS)患者心功能的临床意义。方法:研究对象包括连续50例急诊ACS患者(病例组)和同期本院门诊及体检的35例正常人(对照组),两组均行常规经胸超声心动图,并应用组织多普勒(TDI)测定所有患者的Tei指数,比较组间TDI-Tei指数及相关收缩指数和舒张指数的差异,病例组均进行了冠脉造影并再血管化治疗,入院24h内测定NT-proBNP,比较TDI-Tei指数及左室射血分数(LVEF)、E/A值与NT-proBNP的相关性。结果:病例组TDI-Tei指数较对照组显著延长(0.65±0.12vs0.39±0.05,P=0.003),相关收缩指数与舒张指数也显著延长(0.28±0.06vs0.18±0.03,P=0.017;0.36±0.07vs0.21±0.03,P=0.006);病例组TDI-Tei指数与LVEF呈显著负相关(r=-0.558,P=0.000),TDI-Tei指数与NT-proBNP对数值呈显著正相关(r=0.663,P=0.000),LVEF与NT-proBNP对数值呈显著负相关(r=-0.448,P=0.001)。结论:TDI-Tei能较准确的评价急诊ACS患者左室整体功能,与NT-proBNP评价心室功能的相关性良好。
Objective To investigate the clinical value of heart function evaluated by TDI-Tei index and N- terminal pro-brain natriuretie peptide（NT-proBNP） in patients with acute coronary syndrume（ACS）. Methods In emergency room, 50 patients of ACS diagnosed by coronary angiography were concluded in this study, 35 healthy adults were selected as control group. Left ventrieular ejection fraction （LVEF） and TDI-Tei index were measured by eehoeardiography measurement, plasma brain natriuretie peptide （BNP） was also detected. Results There were significant differences in TDI-Tei index, systolic index and diastolic index between the two groups. A negative correlation was found between TDI-Tei index and LVEF （r = -0.558 ,P = 0.000）. A positive correlation was found between LVEF and logNT-proBNP （r = -0.448,P = 0.001 ）. LVEF had negative correlation with logNT-proBNP. Conclusion There are good correlations between BNP, Tei index, cardiac function, and left ventrieular structure. BNP and Tei index can evaluate the heart function generally in patients with ACS.
出处
《实用医学杂志》
CAS
北大核心
2010年第14期2497-2500,共4页
The Journal of Practical Medicine
基金
广东省科技计划项目(编号:2008A030301191
2009B030801256)
