摘要
目的：探讨预测食管癌预后的生物学指标。方法：选择具有相同TNM分期但术后长期生存和短期死亡的两组食管癌各48例，应用自动化图象分析术测定肿瘤细胞DNA含量，用免疫组织化学法测定肿瘤细胞p53表达和PCNA表达。结果：生存超过10年的患者，二倍体的检出率是52．4％（22／42），p53和PCNA过度表达率各为60．4％（29／48）和37．5％（13／48）。3年内死亡者，二倍体的检出率是30．9％（13／42），p53和PCNA过度表达率各为60.4％（29／48）、62．4％（30／48）。结论：P53表达强度与食管癌的TNM分期有关，但与预测食管癌预后的意义不大，PCNA表达和DNA类型是预测食管癌预后的有用指标。
Pn~: TO find some useful tumor -- biological factors in predicting prognosis of c^inoma. Methods:We selected 96 cases with ESCC, of which 48 survived more than 10 years, other 48 survived less than 3 years, and twogroups had similar TMN staging. Ty computer cytophotometric analysis we detected tumor DNA content, by immunohistological methods we investigated p53 expression and PCNA expression. Result: In patients surving more than 10 years, th),and the rate of PCNA overexpression was e rate of diploid was 52. 4% (22/42), the rate of p53 overexpression was 60. 4%(29/48), and the rate of PCNA overexpression was 37. 3% (18/48). In patients surviving less than 3 years, the rate ofdiploid was 30. 9% (13/42 ), the rate of p53 overexpression was 60. 4% (29/48 ), and the rate of PCNA overexpression was62. 4% (30/48 ). Conclusions: The intensity of p53 expression can' t serve as an independent prognostic for ESCC, DNApatten and PCNA expression are useful prognostic for ESCC.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1999年第1期64-66,共3页
Chinese Journal of Cancer
关键词
食管肿瘤
DNA含量
PCNA
P53基因
Esophageal neoplam
DNA content
p53 expression: PCNA expression
Prognosis
